SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

CK Yuen, JY Lam, WM Wong, LF Mak… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

JY Li, CH Liao, Q Wang, YJ Tan, R Luo, Y Qiu, XY Ge - Virus research, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human
coronavirus causing the pandemic of severe pneumonia (Coronavirus Disease 2019 …

[HTML][HTML] Activation and evasion of type I interferon responses by SARS-CoV-2

X Lei, X Dong, R Ma, W Wang, X Xiao, Z Tian… - Nature …, 2020 - nature.com
The pandemic of COVID-19 has posed an unprecedented threat to global public health.
However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host …

[HTML][HTML] SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …

[HTML][HTML] SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

M Shemesh, TE Aktepe, JM Deerain, JL McAuley… - PLoS …, 2021 - journals.plos.org
Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral
infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I …

SARS-CoV-2 nsp5 exhibits stronger catalytic activity and interferon antagonism than its SARS-CoV ortholog

J Chen, Z Li, J Guo, S Xu, J Zhou, Q Chen… - Journal of …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose an
enormous threat to economic activity and public health worldwide. Previous studies have …

SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling …

L Han, MW Zhuang, J Deng, Y Zheng… - Journal of medical …, 2021 - Wiley Online Library
The suppression of types I and III interferon (IFN) responses by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) contributes to the pathogenesis of coronavirus …

[HTML][HTML] SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3

SY Fung, KL Siu, H Lin, ML Yeung… - International Journal of …, 2021 - ncbi.nlm.nih.gov
Suppression of type I interferon (IFN) response is one pathological outcome of the infection
of highly pathogenic human coronaviruses. To effect this, severe acute respiratory syndrome …

Antagonism of type I interferon by severe acute respiratory syndrome coronavirus 2

H Xia, PY Shi - Journal of Interferon & Cytokine Research, 2020 - liebertpub.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular …

[PDF][PDF] SARS-CoV-2 is sensitive to type I interferon pretreatment

KG Lokugamage, A Hage, C Schindewolf, R Rajsbaum… - BioRxiv, 2020 - scienceopen.com
Abstract 1 SARS-CoV-2, a novel coronavirus (CoV), has recently emerged causing an
ongoing outbreak of 2 viral pneumonia around the world. While genetically distinct from the …