Transcriptional control of kidney cancer
DJ Sanchez, MC Simon - Science, 2018 - science.org
Clear cell renal cell carcinoma (ccRCC) is a subtype of kidney cancer characterized by
inactivation of the von Hippel-Lindau (VHL) gene in∼ 90% of patients. VHL is the substrate …
inactivation of the von Hippel-Lindau (VHL) gene in∼ 90% of patients. VHL is the substrate …
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
Inactivation of the von Hippel-Lindau tumor suppressor gene, VHL, is an archetypical tumor-
initiating event in clear cell renal carcinoma (ccRCC) that leads to the activation of hypoxia …
initiating event in clear cell renal carcinoma (ccRCC) that leads to the activation of hypoxia …
[HTML][HTML] The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy
PE Clark - Kidney international, 2009 - Elsevier
The basic biology underlying the development of clear-cell renal cell carcinoma (ccRCC) is
critically dependent on the von Hippel–Lindau gene (VHL), whose protein product is …
critically dependent on the von Hippel–Lindau gene (VHL), whose protein product is …
Downstream targets of VHL/HIF-α signaling in renal clear cell carcinoma progression: mechanisms and therapeutic relevance
Simple Summary Clear cell renal cell carcinoma (ccRCC) progression, which is the most
common form of kidney cancer, is associated with the loss of the Von Hippel-Lindau (VHL) …
common form of kidney cancer, is associated with the loss of the Von Hippel-Lindau (VHL) …
Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice
S Harlander, D Schönenberger, NC Toussaint… - Nature medicine, 2017 - nature.com
Clear cell renal cell carcinomas (ccRCCs) frequently exhibit inactivation of the von Hippel–
Lindau tumor-suppressor gene, VHL, and often harbor multiple copy-number alterations in …
Lindau tumor-suppressor gene, VHL, and often harbor multiple copy-number alterations in …
Molecular biology of kidney cancer
WG Kaelin Jr - Kidney Cancer: Principles and Practice, 2015 - Springer
Clear cell renal carcinoma is the most common form of kidney cancer, which is one of the ten
leading causes of cancer death in the United States. The initial genetic event in most clear …
leading causes of cancer death in the United States. The initial genetic event in most clear …
Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2–Driven VHL−/− Renal Cancer
K Smith, L Gunaratnam, M Morley, A Franovic… - Cancer research, 2005 - AACR
Inactivating mutations in the von Hippel-Lindau (VHL) tumor suppressor gene are
associated with clear cell renal cell carcinoma (VHL−/− RCC), the most frequent malignancy …
associated with clear cell renal cell carcinoma (VHL−/− RCC), the most frequent malignancy …
[PDF][PDF] Implications of VHL-HIF pathway dysregulation in renal cell carcinoma: current therapeutic strategies and challenges
E Jonasch - Kidney Cancer Journal, 2020 - kidney-cancer-journal.com
Kidney cancer is among the 10 most common cancers in both men and women, leading to
approximately 74,000 new cases and to more than 14,000 deaths annually in United States …
approximately 74,000 new cases and to more than 14,000 deaths annually in United States …
[HTML][HTML] Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma
C Sourbier, G Srivastava, MC Ghosh, S Ghosh… - Oncotarget, 2012 - ncbi.nlm.nih.gov
The tumor suppressor gene, Von Hippel-Lindau (VHL), is frequently mutated in the most
common form of kidney cancer, clear cell renal cell carcinoma (CCRCC). In hypoxic …
common form of kidney cancer, clear cell renal cell carcinoma (CCRCC). In hypoxic …
Molecular pathways in renal cell carcinoma—rationale for targeted treatment
WY Kim, WG Kaelin Jr - Seminars in oncology, 2006 - Elsevier
The VHL tumor-suppressor gene is mutated or silenced in most clear cell renal carcinomas
(RCCs). pVHL loss results in the stabilization of the heterodimeric transcription factor …
(RCCs). pVHL loss results in the stabilization of the heterodimeric transcription factor …