During limb development, expression of cathepsin D and B genes prefigure the pattern of
interdigital apoptosis including the differences between the chick and the webbed digits of …

The implication of lysosomes in the activation of physiological cell death (PCD) was
proposed some decades ago. In this work, we show that the expression of the lysosomal …

Cells control their own death through a program termed apoptosis, which is indispensable
for development and homeostasis in all metazoans. Lysosomal cysteine proteases are not …

Apoptotic stimuli have been shown to trigger lysosomal membrane permeability (LMP),
leading to the release of cathepsins, which activate death signaling pathways in the cytosol …

Apoptosis is the major mechanism by which eukaryotic organisms eliminate potentially
dangerous, superfluous and damaged cells. Initially, nuclei and mitochondria were found to …

We investigated the mechanism of lysosome-mediated cell death using purified recombinant
pro-apoptotic proteins, and cell-free extracts from the human neuronal progenitor cell line …

Here, we show a detailed chronotopographical analysis of cathepsin B and D expression
during development of the mouse visual system. Both proteases were detected in large …

The release of cathepsin proteases from disrupted lysosomes results in lethal cellular
autodigestion. Lysosomal disruption-related cell death is highly variable, showing both …

Apoptosis can be mediated by different mechanisms. There is growing evidence that
different proteolytic enzymes are involved in the regulation of apoptosis. Cathepsins are …

Two major apoptotic signaling pathways have been defined in mammals, the extrinsic
pathway, initiated by ligation of death receptors, and the intrinsic pathway, triggered by …