Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Transmission of external stimuli to intracellular effector proteins via signalling …

Progressive weight loss combined with skeletal muscle atrophy, termed cachexia, is a
common comorbidity associated with cancer that results in adverse consequences for the …

There is no universal approach to stop muscle cachexia in a number of lifethreatening
diseases. Accordingly, it is uncertain why the body mass is so critical to keep alive patients …

Besides its primary function in locomotion, skeletal muscle (SKM), which represents up to
half of human's weight, also plays a fundamental homeostatic role. Through the secretion of …

Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

Background Cachexia is a multi-factorial, systemic syndrome that especially affects patients
with cancer of the gastrointestinal tract, and leads to reduced treatment response, survival …

Cancer cachexia is a metabolic syndrome that can be present even in the absence of weight
loss ('precachexia'). Cachexia is often compounded by pre-existing muscle loss, and is …

Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional
intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and …

Cancer cachexia is a debilitating consequence of disease progression, characterised by the
significant weight loss through the catabolism of both skeletal muscle and adipose tissue …