Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex
COVID-19 rapidly emerged as a crippling public health crisis in the last few months, which
has presented a series health risk. Understanding of the immune response and biomarker …
has presented a series health risk. Understanding of the immune response and biomarker …
[HTML][HTML] Longitudinal cytokine profile in patients with mild to critical COVID-19
The cytokine release syndrome has been proposed as the driver of inflammation in
coronavirus disease 2019 (COVID-19). However, studies on longitudinal cytokine profiles in …
coronavirus disease 2019 (COVID-19). However, studies on longitudinal cytokine profiles in …
Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
Attenuating the effects of novel COVID-19 (SARS-CoV-2) infection-induced cytokine storm and the implications
AB Rowaiye, OA Okpalefe… - Journal of …, 2021 - Taylor & Francis
The COVID-19 pandemic constitutes an arduous global health challenge, and the
increasing number of fatalities calls for the speedy pursuit of a remedy. This review …
increasing number of fatalities calls for the speedy pursuit of a remedy. This review …
Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes
D Zhang, R Guo, L Lei, H Liu, Y Wang… - Journal of Leucocyte …, 2021 - academic.oup.com
Excessive monocyte/macrophage activation with the development of a cytokine storm and
subsequent acute lung injury, leading to acute respiratory distress syndrome (ARDS), is a …
subsequent acute lung injury, leading to acute respiratory distress syndrome (ARDS), is a …
[HTML][HTML] Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent
BACKGROUND Coronavirus disease 19 (COVID-19) is an emerging infectious disease
caused by SARS-CoV-2. Antiviral immune response is crucial to achieve pathogen …
caused by SARS-CoV-2. Antiviral immune response is crucial to achieve pathogen …
[HTML][HTML] Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients
ZS Xu, T Shu, L Kang, D Wu, X Zhou, BW Liao… - Signal transduction and …, 2020 - nature.com
In December 2019, a novel coronavirus that is related to severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) in …
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) in …
[HTML][HTML] Immune Response and COVID-19: A mirror image of Sepsis
E López-Collazo, J Avendano-Ortiz… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 virus and its associated disease COVID-19 have triggered
significant threats to public health, in addition to political and social changes. An important …
significant threats to public health, in addition to political and social changes. An important …
A neutrophil activation signature predicts critical illness and mortality in COVID-19
Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-
19, but the mechanisms involved remain poorly understood. We carried out proteomic …
19, but the mechanisms involved remain poorly understood. We carried out proteomic …
[HTML][HTML] Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19
JT Sims, V Krishnan, CY Chang, SM Engle… - Journal of Allergy and …, 2021 - Elsevier
Background Physicians treating patients with coronavirus disease 2019 (COVID-19)
increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a …
increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a …