Clinical implications of cancer stem cell biology in hepatocellular carcinoma

J Ji, XW Wang - Seminars in oncology, 2012 - Elsevier
Solid tumors are thought to contain cancer stem cells (CSCs) as a distinct population
responsible for tumor relapse and metastasis due to their abilities to self-renew, differentiate …

Cancer stem cells in hepatocellular carcinoma: therapeutic implications based on stem cell biology

T Chiba, A Iwama, O Yokosuka - Hepatology Research, 2016 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most
frequent cause of cancer‐related death worldwide. Despite advances in its diagnosis and …

Cancer stem cells in the development of liver cancer

T Yamashita, XW Wang - The Journal of clinical …, 2013 - Am Soc Clin Investig
Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor
markers are useful for isolating a subset of liver cells with stem cell features, known as …

Liver cancer stem cells: implications for a new therapeutic target

TKW Lee, A Castilho, S Ma, IOL Ng - Liver International, 2009 - Wiley Online Library
Hepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current
therapeutic strategies against this disease target mostly rapidly growing differentiated …

Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications

TKW Lee, XY Guan, S Ma - Nature reviews Gastroenterology & …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

[HTML][HTML] Liver cancer stem cell markers: progression and therapeutic implications

JH Sun, Q Luo, LL Liu, GB Song - World journal of …, 2016 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) are a small subpopulation in cancer, have been proposed to be
cancer-initiating cells, and have been shown to be responsible for chemotherapy resistance …

Cancer stem cell as a potential therapeutic target in hepatocellular carcinoma

R WC Pang, R TP Poon - Current Cancer Drug Targets, 2012 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is one of the most common human cancers. HCC is a
chemoresistant cancer and the current drug therapy has limited efficacy. As a result, the …

Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective

T Chiba, A Kamiya, O Yokosuka, A Iwama - Cancer letters, 2009 - Elsevier
Although the “cancer stem cell (CSC)” hypothesis was first proposed roughly 50years ago,
recent progress in stem cell biology and technologies has successfully achieved the …

The power and the promise of liver cancer stem cell markers

LL Liu, D Fu, Y Ma, XZ Shen - Stem cells and development, 2011 - liebertpub.com
Recently, there has been growing support for the cancer stem cell (CSC) hypothesis, which
states that primary tumors are initiated and maintained by a small subpopulation of cancer …

Cancer stem cells in hepatocellular carcinoma: intrinsic and extrinsic molecular mechanisms in stemness regulation

X Fang, Q Yan, S Liu, XY Guan - International journal of molecular …, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) remains the most predominant type of liver cancer with an
extremely poor prognosis due to its late diagnosis and high recurrence rate. One of the …