Targeting SOX2 in anticancer therapy
L Hüser, D Novak, V Umansky, P Altevogt… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: SOX2 is a transcription factor that is important in the development and
maintenance of the stem cell state. Furthermore, SOX2 is associated with cancer …
maintenance of the stem cell state. Furthermore, SOX2 is associated with cancer …
[HTML][HTML] The dark side of SOX2: cancer-a comprehensive overview
EL Wuebben, A Rizzino - Oncotarget, 2017 - ncbi.nlm.nih.gov
The pluripotency-associated transcription factor SOX2 is essential during mammalian
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …
[HTML][HTML] SOX2 in development and cancer biology
D Novak, L Hüser, JJ Elton, V Umansky… - Seminars in cancer …, 2020 - Elsevier
The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …
role in maintaining the stemness of embryonic cells and various adult stem cell populations …
Functional characterization of SOX2 as an anticancer target
S Zhang, X Xiong, Y Sun - Signal transduction and targeted therapy, 2020 - nature.com
SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …
[HTML][HTML] SOX2 function in cancers: Association with growth, invasion, stemness and therapy response
S Mirzaei, MDA Paskeh, M Entezari… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of death worldwide and around 10 million deaths in 2020 were
related to cancer. There are a number of therapeutic modalities for cancer such as …
related to cancer. There are a number of therapeutic modalities for cancer such as …
[HTML][HTML] SOX2-associated signaling pathways regulate biological phenotypes of cancers
LN Ding, YY Yu, CJ Ma, CJ Lei, HB Zhang - Biomedicine & …, 2023 - Elsevier
SOX2 is a transcription factor involved in multiple stages of embryonic development. In
related reports, SOX2 was found to be abnormally expressed in tumor tissues and correlated …
related reports, SOX2 was found to be abnormally expressed in tumor tissues and correlated …
SOX2 and cancer: current research and its implications in the clinic
K Weina, J Utikal - Clinical and translational medicine, 2014 - Springer
SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …
Targeting oncogenic SOX2 in human cancer cells: therapeutic application
S Zhang, Y Sun - Protein & Cell, 2020 - academic.oup.com
Sry-related high-mobility box 2 (SOX2) is a critical transcription factor that plays an important
role in various phases of embryonic development and maintenance of undifferentiated …
role in various phases of embryonic development and maintenance of undifferentiated …
SOX9: An emerging driving factor from cancer progression to drug resistance
Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …
Sox2: a regulatory factor in tumorigenesis and metastasis
S Chaudhary, Z Islam, V Mishra… - Current Protein and …, 2019 - ingentaconnect.com
The transcription factor Sox2 plays an important role in various phases of embryonic
development, including cell fate and differentiation. These key regulatory functions are …
development, including cell fate and differentiation. These key regulatory functions are …