Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders

H Zhao, DR Nyholt - Human genetics, 2017 - Springer
Studies using genome-wide association (GWA) single nucleotide polymorphism (SNP) level
data have indicated genetic overlap across the five major disorders in the Psychiatric …

Genomewide association studies: history, rationale, and prospects for psychiatric disorders

Psychiatric GWAS Consortium … - American Journal of …, 2009 - Am Psychiatric Assoc
Objective: The authors conducted a review of the history and empirical basis of genomewide
association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date …

[HTML][HTML] Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders

X Yao, JT Glessner, J Li, X Qi, X Hou, C Zhu… - Translational …, 2021 - nature.com
Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …

Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder

TG Schulze, N Akula, R Breuer, J Steele… - The World Journal of …, 2014 - Taylor & Francis
Objectives. Genome-wide association studies (GWAS) in complex phenotypes, including
psychiatric disorders, have yielded many replicated findings, yet individual markers account …

Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders

EM Byrne, Z Zhu, T Qi, NG Skene, J Bryois… - Molecular …, 2021 - nature.com
Substantial genetic liability is shared across psychiatric disorders but less is known about
risk variants that are specific to a given disorder. We used multi-trait conditional and joint …

Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in …

V Moskvina, N Craddock, P Holmans, I Nikolov… - Molecular …, 2009 - nature.com
Genome-wide association (GWAS) analyses have identified susceptibility loci for many
diseases, but most risk for any complex disorder remains unattributed. There is therefore …

A framework for interpreting genome-wide association studies of psychiatric disorders.

P Sullivan - Molecular psychiatry, 2009 - psycnet.apa.org
Genome-wide association studies (GWAS) have yielded a plethora of new findings in the
past 3 years. By early 2009, GWAS on 47 samples of subjects with attention-deficit …

[HTML][HTML] Horizons of psychiatric genetics and epigenetics: where are we and where are we heading?

HM Abdolmaleky - Iranian Journal of Psychiatry and Behavioral …, 2014 - ncbi.nlm.nih.gov
Today multinational studies using genome-wide association scan (GWAS) for> 1000, 000
polymorphisms on> 100,000 cases with major psychiatric diseases versus controls …

[HTML][HTML] Multi-trait analysis for genome-wide association study of five psychiatric disorders

Y Wu, H Cao, A Baranova, H Huang, S Li, L Cai… - Translational …, 2020 - nature.com
We conducted a cross-trait meta-analysis of genome-wide association study on
schizophrenia (SCZ)(n= 65,967), bipolar disorder (BD)(n= 41,653), autism spectrum …

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

SH Lee, S Ripke, BM Neale, SV Faraone… - Nature …, 2013 - cdr.lib.unc.edu
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …