Abstract Background/Aims Pragmatic clinical trials (PCTs) represent an increasingly used
strategy for “real-world” trials. Successful PCTs typically require participation of community …

This second article in the series on pragmatic trials describes the challenges in selection of
sites for pragmatic clinical trials and the impact on validity, precision, and generalizability of …

Pragmatic clinical trials are increasingly common because they have the potential to yield
findings that are directly translatable to real-world healthcare settings. Pragmatic clinical …

An important challenge in comparative effectiveness research is the lack of infrastructure to
support pragmatic clinical trials, which compare interventions in usual practice settings and …

Introduction Despite the proliferation of pragmatic clinical trials (PCTs) conducted in health
care delivery settings, we know relatively little about how practicing clinicians perceive their …

Abstract The National Institutes of Health (NIH) Health Care Systems (HCS) Research
Collaboratory hosted a workshop to explore challenges and strategies for the dissemination …

Objective We established a large database of trials to serve as a resource for future
methodological and ethical analyses. Here, we use meta-data to describe the broad …

Explanatory and pragmatic trials represent ends of a continuum of attitudes about clinical
trial design. Recent literature argues that pragmatic trials are more informative about clinical …

Background The clinical research enterprise is not producing the evidence decision makers
arguably need in a timely and cost effective manner; research currently involves the use of …

Aim: Practicing physicians inevitably become involved in pragmatic clinical trials (PCTs),
including comparative effectiveness research. We sought to identify physicians' perspectives …