BACKGROUND: Sepsis and secondary multiple organ failure in critically ill patients are the
major cause of death, but the pathogenesis of sepsis is not clear, especially the dysfunction …

Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection, and it affects over 25 million people every year. Even more …

Strategies for blocking the systemic effects of cytokines in... : Critical Care Medicine Strategies
for blocking the systemic effects of cytokines in the sepsis syndrome : Critical Care Medicine …

Sepsis–the most common cause of death in hospitalized patients–affects over 18 million
people worldwide and has an expected 1% increase of incidence per year. Recent clinical …

Introduction: Sepsis is a major cause of death worldwide but its orchestrating components
remain incompletely understood. On the one hand, development of sepsis results from an …

Although data with regard to cytokine action are rapidly emerging at the molecular and cell
level, animal and human data are lagging. Deciphering the mechanisms of action and …

The morbidity and mortality attending episodes of sepsis remain high despite widespread
advances in technologies directed at support of systemic hemo-dynamic performance and …

Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical
syndrome related to the host response to infection. The severity of infections is due to an …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

The underlying principles of sepsis therapy have remained unchanged for decades. These
include: prompt institution of antimicrobial agents aimed at the inciting pathogen, source …