Sepsis is a major cause of morbidity and mortality among hospitalized patients and the
leading cause of death among patients admitted to intensive care units. The immune …

Septic syndromes still remain a major but largely under-recognized healthcare problem
worldwide accounting for thousands of deaths every year. Despite numerous clinical trials …

For many years, basic research with relatively straightforward pathophysiologic approaches
has driven clinical trials using molecules that supposedly interfere positively with …

Although microbes and their associated toxins initiate sepsis, it is the subsequent host
inflammatory response that defines most of what we characterize as clinical sepsis. This …

Despite intensive ongoing research efforts, the mortality of patients with sepsis remains
unacceptably high. Clinical trials emerging from promising results in animal models have …

Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …

Sepsis is a systemic inflammatory response syndrome in response to severe infection. An
overwhelming systemic response brought about by the release of various inflammatory …

The complex interaction between microorganisms, the host's immune response, and the
release of pro-and anti-inflammatory factors influence the evolution of sepsis. According to …

Sepsis and its sequelae are still a major cause of morbidity and mortality on today's
intensive care units. The evidence that primary responses in sepsis are mediated by …

Despite important advances in critical care medicine during the last two decades, the
mortality rate of sepsis has remained high, probably because the pathogenesis of sepsis is …