Sepsis results from the activation of a complex cascade of mediators, an appropriate and
necessary body response to infection or insult which can, however, become excessive and …

Despite advances in the development of powerful antibiotics and intensive care unit, sepsis
is still life threatening and the mortality rate remains unchanged for the past three decades …

Sepsis with subsequent multiple organ dysfunction is a distinctly systemic inflammatory
response to concealed or known infection and is a leading cause of death in intensive care …

Our understanding of sepsis and its resultant outcomes remains a paradox. On the one
hand, we know more about the pathophysiology of sepsis than ever before. However, this …

The systemic inflammatory response syndrome (SIRS) is the predominantly cytokine-
mediated, pro-inflammatory response of the host to invading pathogens and is considered …

Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …

The outcome of patients with sepsis arises from multiple factors affecting both the host and
the invading microorganisms. Age, presence of underlying disease, source of infection and …

Much research over the past 30 to 40 years has shown that the inflammatory response,
while critical for host defense during microbial infection, may itself play a central role in the …

Human sepsis is associated with the activation and systemic expression of host
inflammatory pathways via stimulation of the host immune effector cells to synthesize and …

The systemic inflammatory response syndrome (SIRS) and sepsis are accompanied by a
complex, unbalanced and often fatal activation of the immune and inflammatory systems …