Tumor-specific expansion of oxidative stress by glutathione depletion and use of a fenton nanoagent for enhanced chemodynamic therapy

Q Chen, J Zhou, Z Chen, Q Luo, J Xu… - ACS applied materials & …, 2019 - ACS Publications
Amplifying intracellular oxidative stress effectively destroys cancer cells. In addition, iron-
mediated Fenton reaction converts endogenous H2O2 to produce hypertoxic hydroxyl …

Biomimetic nanoplatform with H2O2 homeostasis disruption and oxidative stress amplification for enhanced chemodynamic therapy

LH Fu, XY Wu, J He, C Qi, J Lin, P Huang - Acta Biomaterialia, 2023 - Elsevier
Chemodynamic therapy (CDT) is a powerful cancer treatment strategy by producing
excessive amount of reactive oxygen species (ROS) to kill cancer cells. However, the …

Self-sufficient copper peroxide loaded pKa-tunable nanoparticles for lysosome-mediated chemodynamic therapy

H Deng, Z Yang, X Pang, C Zhao, J Tian, Z Wang… - Nano Today, 2022 - Elsevier
Chemodynamic therapy (CDT) has recently gained much attention for Fenton chemistry-
mediated cancer treatment, but the anti-tumor efficacy of CDT suffers from insufficient …

Intelligent nanoplatform with multi therapeutic modalities for synergistic cancer therapy

L Shao, T Hu, X Fan, X Wu, F Zhou… - … Applied Materials & …, 2022 - ACS Publications
Chemodynamic therapy (CDT) has attracted increasing attention in tumor treatment but is
limited by insufficient endogenous H2O2. Moreover, it is challenging for monotherapy to …

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

H Tian, M Zhang, G Jin, Y Jiang, Y Luan - Journal of Colloid and Interface …, 2021 - Elsevier
Chemodynamic therapy (CDT) utilizes Fenton catalysts to convert intracellular hydrogen
peroxide (H 2 O 2) into cytotoxic hydroxyl radical (OH∙) for tumor therapy, but endogenous H …

Boosting tumor treatment by dredging the hurdles of chemodynamic therapy synergistic ion therapy

J Liu, Y Jin, Z Song, L Xu, Y Yang, X Zhao… - Chemical Engineering …, 2021 - Elsevier
Although chemodynamic therapy (CDT) holds the advantage of tumor treatment by
generating hydroxyl radicals (· OH) without the participation of O 2, insufficient H 2 O 2 and …

Hydrogen peroxide-generating nanomedicine for enhanced chemodynamic therapy

P Yu, X Li, G Cheng, X Zhang, D Wu, J Chang… - Chinese Chemical …, 2021 - Elsevier
Chemodynamic therapy (CDT) is an emerging endogenous stimulation activated tumor
treatment approach that exploiting iron-containing nanomedicine as catalyst to convert …

Biomimetic yolk–shell nanocatalysts for activatable dual-modal-image-guided triple-augmented chemodynamic therapy of cancer

Y Pan, Y Zhu, C Xu, C Pan, Y Shi, J Zou, Y Li, X Hu… - ACS …, 2022 - ACS Publications
Fenton reaction-based chemodynamic therapy (CDT), which applies metal ions to convert
less active hydrogen peroxide (H2O2) into more harmful hydroxyl peroxide (· OH) for tumor …

Tumor microenvironment responsive biomimetic copper peroxide nanoreactors for drug delivery and enhanced chemodynamic therapy

S Hou, YE Gao, X Ma, Y Lu, X Li, J Cheng, Y Wu… - Chemical Engineering …, 2021 - Elsevier
Facing the multiple and arduous characteristics of tumors, chemodynamic therapy (CDT) is
an emerging therapeutic approach. It uses toxic hydroxyl radical (∙ OH) produced by Fenton …

Amplification of tumor oxidative stresses with liposomal fenton catalyst and glutathione inhibitor for enhanced cancer chemotherapy and radiotherapy

Z Dong, L Feng, Y Chao, Y Hao, M Chen, F Gong… - Nano …, 2018 - ACS Publications
Amplification of intracellular oxidative stress has been found to be an effective strategy to
induce cancer cell death. To this end, we prepare a unique type of ultrasmall gallic acid …