Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia

A Vitiello, F Ferrara, C Pelliccia, G Granata… - Italian Journal of …, 2020 - italjmed.org
For some patients with SARS-CoV-2, the worst clinical damage is not caused by the virus
itself, but by an overactive inflammatory state. In fact, in some people the immune system …

Potential role of interferons in treating COVID-19 patients

MH Abdolvahab, S Moradi-Kalbolandi, M Zarei… - International …, 2021 - Elsevier
The recently public health crises in the world is emerged by spreading the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) also named COVID-19. The virus is …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
Introduction The cytokine release syndrome (CRS) of COVID-19 is associated with the
development of critical illness requiring multi-organ support. Further research is required to …

Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
Balanced immune regulation is crucial for recognizing an invading pathogen, its killing, and
elimination. Toll‐like receptors (TLRs) are the key regulators of the innate immune system. It …

COVID-19–Considerations for the paediatric rheumatologist

CM Hedrich - Clinical Immunology, 2020 - Elsevier
The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes
across the globe. A significant proportion of adult patients require hospitalisation and may …

COVID-19 as an acute inflammatory disease

RH Manjili, M Zarei, M Habibi… - The journal of immunology, 2020 - journals.aai.org
Abstract The 2019 coronavirus disease (COVID-19) pandemic caused by the virus severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created an unprecedented …

[HTML][HTML] Why COVID-19 is less frequent and severe in children: a narrative review

R Sinaei, S Pezeshki, S Parvaresh, R Sinaei - World Journal of Pediatrics, 2021 - Springer
Background Despite the streaks of severity, severe acute respiratory syndrome-coronavirus-
2 (SARS-CoV-2) infection is, in general, less frequent and severe in children than in adults …

Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer

H Shuai, H Chu, Y Hou, D Yang, Y Wang, B Hu… - Journal of Infection, 2020 - Elsevier
Objectives Respiratory and intestinal tract are two primary target organs of SARS-CoV-2
infection. However, detailed characterization of the host-virus interplay in infected human …

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
The outbreak of the novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)
responsible for coronavirus disease 2019 (COVID-19) has developed into an …

SARS‐CoV‐2 infection, COVID‐19 pathogenesis, and exposure to air pollution: What is the connection?

B Woodby, MM Arnold… - Annals of the new York …, 2021 - Wiley Online Library
Exposure to air pollutants has been previously associated with respiratory viral infections,
including influenza, measles, mumps, rhinovirus, and respiratory syncytial virus …