Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered.
The identification of sulfanilamide as the active component of the dye Prontosil rubrum led to …

Dihydropterate synthase (DHPS) is the target for the sulfonamide class of antibiotics, but
increasing resistance has encouraged the development of new therapeutic agents against …

The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the
folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have …

Dihydropteroate synthase (DHPS) is a key enzyme in bacterial folate synthesis and the
target of the sulfonamide class of antibacterials. Resistance and toxicities associated with …

The enzyme 6-hydroxymethyl-7, 8-dihydropteroate synthase (DHPS) catalyzes the
condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin …

The sulfonamides (sulfas) are the oldest class of antibacterial drugs and inhibit the bacterial
dihydropteroate synthase (DHPS, encoded by folP), through chemical mimicry of its co …

Staphylococcal species are a leading cause of bacterial drug-resistant infections and
associated mortality. One strategy to combat bacterial drug resistance is to revisit …

The gene encoding the dihydropteroate synthase of staphylococcus aureus has been
cloned, sequenced and expressed in Escherichia coli. The protein has been purified for …

Sulfonamides are synthetic chemotherapeutic agents that work as competitive inhibitors of
the di-hydro-pteroate synthase (DHPS) enzyme, encoded by the folP gene. Resistance to …

More research effort needs to be invested in antimicrobial drug development to address the
increasing threat of multidrug-resistant organisms. The enzyme DHPS has been a validated …