Epoxide syntheses and ring-opening reactions in drug development

F Moschona, I Savvopoulou, M Tsitopoulou, D Tataraki… - Catalysts, 2020 - mdpi.com
This review concentrates on success stories from the synthesis of approved medicines and
drug candidates using epoxide chemistry in the development of robust and efficient …

Ring opening reactions of epoxides. A review

M Thirumalaikumar - Organic Preparations and Procedures …, 2022 - Taylor & Francis
Epoxides are valuable intermediates for the stereocontrolled synthesis of complex organic
compounds, and their utility has expanded dramatically with the advent of practical …

Advances in homogeneous and heterogeneous catalytic asymmetric epoxidation

QH Xia, HQ Ge, CP Ye, ZM Liu, KX Su - Chemical Reviews, 2005 - ACS Publications
Barry Sharpless was awarded the 2001 Nobel Prize as a compliment to his great
contributions in the field of asymmetric epoxidation, which has been recognized as one of …

Catalytic asymmetric synthesis of epoxides mediated by chiral iminium salts

VK Aggarwal, MF Wang - Chemical Communications, 1996 - pubs.rsc.org
The catalytic asymmetric oxidation of unfunctionalised alkenes is achieved by a non-
transition metal catalysed process; just 5 mol% of the binaphthyl-based iminium salt 1 is …

The catalytic enantioselective synthesis of optically active epoxides and tetrahydrofurans. Asymmetric epoxidation, the desymmetrization of meso-tetrahydrofurans …

T Katsuki - Current Organic Chemistry, 2001 - ingentaconnect.com
Recent developments in metallosalen-catalyzed asymmetric oxidation, namely, the
epoxidation of simple olefins and the desymmetrization of meso-tetrahydrofurans by using …

Asymmetric catalysis of epoxide ring-opening reactions

EN Jacobsen - Accounts of chemical research, 2000 - ACS Publications
The discovery of the metal salen-catalyzed asymmetric ring-opening (ARO) of epoxides is
chronicled. A screening approach was adopted for the identification of catalysts for the …

General method for the synthesis of high enantiomeric purity chiral epoxides

WH Pirkle, PL Rinaldi - The Journal of Organic Chemistry, 1978 - ACS Publications
Ring opening of racemic epoxides with thiophenoxide anion affords 0-hydroxy sulfides (3),
which can be resolved by chromatographic separation of their diastereomeric 1-(1-naphthyl) …

New C2-symmetric chiral ketones for catalytic asymmetric epoxidation of unfunctionalized olefins

CE Song, YH Kim, KC Lee, S Lee, BW Jin - Tetrahedron: Asymmetry, 1997 - Elsevier
New &symmetric chiral ketones for catalytic asymmetric epoxidation of unfunctionalized
olefins Page 1 Pergamon Rwahednm: Asymmcrry. Vol. 8. No. 17, pp. 2921-2926, 1997 8 1997 …

Designing New Chiral Ketone Catalysts. Asymmetric Epoxidation of cis-Olefins and Terminal Olefins

H Tian, X She, H Yu, L Shu, Y Shi - The Journal of organic …, 2002 - ACS Publications
This paper describes a new class of chiral oxazolidinone ketone catalyst for asymmetric
epoxidation. High ee values have been obtained for a number of cyclic and acyclic cis …

Enantioselective Epoxidation of Conjugated cis-Enynes by Chiral Dioxirane

CP Burke, Y Shi - The Journal of Organic Chemistry, 2007 - ACS Publications
This paper describes a highly chemo-and enantioselective epoxidation of conjugated cis-
enynes using readily available glucose-derived ketone 2 as catalyst and Oxone as oxidant …