[HTML][HTML] Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates
S Reynard, E Gloaguen, N Baillet… - PLoS Neglected …, 2021 - journals.plos.org
Ebola virus has been responsible for two major epidemics over the last several years and
there has been a strong effort to find potential treatments that can improve the disease …
there has been a strong effort to find potential treatments that can improve the disease …
[HTML][HTML] Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques
J Guedj, G Piorkowski, F Jacquot, V Madelain… - PLoS …, 2018 - journals.plos.org
Background Despite repeated outbreaks, in particular the devastating 2014–2016 epidemic,
there is no effective treatment validated for patients with Ebola virus disease (EVD). Among …
there is no effective treatment validated for patients with Ebola virus disease (EVD). Among …
[HTML][HTML] Intracellular conversion and in vivo dose response of favipiravir (T-705) in rodents infected with Ebola virus
SL Bixler, TM Bocan, J Wells, KS Wetzel… - Antiviral research, 2018 - Elsevier
Abstract During the 2013–2016 Ebola virus (EBOV) outbreak in West Africa, our team at
USAMRIID evaluated the antiviral activity of a number of compounds, including favipiravir (T …
USAMRIID evaluated the antiviral activity of a number of compounds, including favipiravir (T …
Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates
V Madelain, A Duthey, F Mentré, F Jacquot, C Solas… - Antiviral Research, 2020 - Elsevier
Background In spite of recurrent and dramatic outbreaks, there are no therapeutics
approved against Ebola virus disease. Favipiravir, a RNA polymerase inhibitor active …
approved against Ebola virus disease. Favipiravir, a RNA polymerase inhibitor active …
Laboratory findings, compassionate use of favipiravir, and outcome in patients with Ebola virus disease, Guinea, 2015—a retrospective observational study
R Kerber, E Lorenz, S Duraffour… - The Journal of …, 2019 - academic.oup.com
Background In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea,
confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola …
confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola …
Recent progress on the treatment of Ebola virus disease with Favipiravir and other related strategies
T Zhang, M Zhai, J Ji, J Zhang, Y Tian, X Liu - Bioorganic & medicinal …, 2017 - Elsevier
Ebola virus is one of the most threatening pathogens with the mortality rate as high as 90%
in the world. There are no licensed therapeutic drugs or preventive vaccines for Ebola …
in the world. There are no licensed therapeutic drugs or preventive vaccines for Ebola …
[HTML][HTML] Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
L Oestereich, A Lüdtke, S Wurr, T Rieger… - Antiviral research, 2014 - Elsevier
Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case
fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is …
fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is …
[HTML][HTML] Experimental treatment with favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea
D Sissoko, C Laouenan, E Folkesson… - PLoS …, 2016 - journals.plos.org
Background Ebola virus disease (EVD) is a highly lethal condition for which no specific
treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak …
treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak …
[HTML][HTML] Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies
V Madelain, S Baize, F Jacquot, S Reynard… - Nature …, 2018 - nature.com
Despite several clinical trials implemented, no antiviral drug could demonstrate efficacy
against Ebola virus. In non-human primates, early initiation of polymerase inhibitors …
against Ebola virus. In non-human primates, early initiation of polymerase inhibitors …
[HTML][HTML] Efficacy of favipiravir (T-705) in nonhuman primates infected with Ebola virus or Marburg virus
SL Bixler, TM Bocan, J Wells, KS Wetzel… - Antiviral Research, 2018 - Elsevier
Favipiravir is a broad-spectrum antiviral agent that has demonstrated efficacy against Ebola
virus (EBOV) in rodents. However, there are no published reports of favipiravir efficacy for …
virus (EBOV) in rodents. However, there are no published reports of favipiravir efficacy for …