Ebola virus altered innate and adaptive immune response signalling pathways: Implications for novel therapeutic approaches

A Kumar - Infectious Disorders-Drug Targets (Formerly Current …, 2016 - ingentaconnect.com
Ebola virus (EBOV) arise attention for their impressive lethality by the poor immune
response and high inflammatory reaction in the patients. It causes a severe hemorrhagic …

Ebola virus dynamics in mice treated with favipiravir

V Madelain, L Oestereich, F Graw, THT Nguyen… - Antiviral research, 2015 - Elsevier
The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease.
Here, we designed a mathematical model to characterize the viral dynamics in 20 mice …

[PDF][PDF] May early intervention with intravenous immunoglobulin pose a potentially successful treatment for Ebola virus infection?

Y Ge, TS Li - Science China. Life Sciences, 2015 - cyberleninka.org
Ebola virus is negative-sense, single stranded RNA virus of the family Filoviridae. Since their
discovery in 1976, Ebola viruses have caused numerous outbreaks of severe hemorrhagic …

Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus

KY Lai, WYG Ng, FF Cheng - Infectious diseases of poverty, 2014 - Springer
The recent outbreak of the human Zaire ebolavirus (EBOV) epidemic is spiraling out of
control in West Africa. Human EBOV hemorrhagic fever has a case fatality rate of up to 90 …

[PDF][PDF] Past, present and future about Ebola virus diseases: An updated review

A Mali, B Swapnil, J Pooja, M Dwaraka… - Journal of Pharmacy …, 2016 - jppcm.org
Ebola virus is responsible for the Ebola virus diseases. The epidemic of Ebola hemorrhagic
fever is a deadly disease of animal can also be transmitted to human and non-human …

Immunological perspective for Ebola virus infection and various treatment measures taken to fight the disease

S Jain, SF Khaiboullina, M Baranwal - Pathogens, 2020 - mdpi.com
Ebolaviruses, discovered in 1976, belongs to the Filoviridae family, which also includes
Marburg and Lloviu viruses. They are negative-stranded RNA viruses with six known …

Ebolavirus: a brief review of novel therapeutic targets

AS Kondratowicz, WJ Maury - Future microbiology, 2012 - Taylor & Francis
Dysregulated host immune responses: can we alter the outcome? As with other viral
infections, initial induction of type 1 IFNs are likely to elicit subsequent productive immune …

Discovering drugs for the treatment of Ebola virus

SL Bixler, AJ Duplantier, S Bavari - Current Treatment Options in Infectious …, 2017 - Springer
Opinion statement Purpose of review Ebola virus, a member of the Filoviridae family, is a
causative agent of severe viral hemorrhagic fever in humans. Over the past 40 years, the …

Ebola virus disease in humans: pathophysiology and immunity

C Muñoz-Fontela, AK McElroy - Marburg-and ebolaviruses: From …, 2017 - Springer
Viruses of the Ebolavirus genus cause sporadic epidemics of severe and systemic febrile
disease that are fueled by human-to-human transmission. Despite the notoriety of …

Effective treatment strategies against Ebola virus

A Yaqoob, U Shehzad, Z Ahmad, N Naseer… - Advancements in Life …, 2015 - als-journal.com
Ebola virus (EBOV), a member of order Mononegavirales is most famous for causing the
endemics of hemorrhagic fever in different countries of the world. Various effective treatment …