Psychiatric genomics: an update and an agenda

PF Sullivan, A Agrawal, CM Bulik… - American Journal of …, 2018 - Am Psychiatric Assoc
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of
psychiatry. This global effort is dedicated to rapid progress and open science, and in the …

[HTML][HTML] Translating insights from neuropsychiatric genetics and genomics for precision psychiatry

E Rees, MJ Owen - Genome Medicine, 2020 - Springer
The primary aim of precision medicine is to tailor healthcare more closely to the needs of
individual patients. This requires progress in two areas: the development of more precise …

Psychiatric genetics and the structure of psychopathology

JW Smoller, OA Andreassen, HJ Edenberg… - Molecular …, 2019 - nature.com
For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …

[HTML][HTML] Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice

JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …

Ten challenges for clinical translation in psychiatric genetics

EM Derks, JG Thorp, ZF Gerring - Nature genetics, 2022 - nature.com
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

Schizophrenia: a review of genetic studies

MT Tsuang, WS Stone, SV Faraone - Harvard Review of Psychiatry, 1999 - Taylor & Francis
Despite the complexities of schizophrenia, notable progress has been achieved in its
diagnosis and treatment over the last 25 years. In this article we review the genetic research …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

[PDF][PDF] Endophenotypes in studies of the genetics of schizophrenia

DL Braff, R Freedman - … : The Fifth Generation of Progress: An Official …, 2002 - Citeseer
The power and appeal of the molecular biology mantra,''DNA to RNA to protein,''to explicate
cell biology comes from its universal appearance and application in all species, from …

[HTML][HTML] Will the genomics revolution revolutionize psychiatry?

KR Merikangas, N Risch - American Journal of Psychiatry, 2003 - Am Psychiatric Assoc
At the time DNA was discovered 50 years ago, psychiatric genetics was in a state of relative
dormancy, resulting from the misuse of genetic theories during the World War II era. As the …

The genomic psychiatry cohort: partners in discovery

MT Pato, JL Sobell, H Medeiros… - American Journal of …, 2013 - Wiley Online Library
Abstract The Genomic Psychiatry Cohort (GPC) is a longitudinal resource designed to
provide the necessary population‐based sample for large‐scale genomic studies, studies …