Mechanistic analysis of enhancer sequences in the Estrogen Receptor transcriptional program
Estrogen Receptor α (ERα) is a major lineage determining transcription factor (TF) in
mammary gland development. Dysregulation of ERα-mediated transcriptional program …
mammary gland development. Dysregulation of ERα-mediated transcriptional program …
Enhancer transcripts mark active estrogen receptor binding sites
N Hah, S Murakami, A Nagari, CG Danko… - Genome …, 2013 - genome.cshlp.org
We have integrated and analyzed a large number of data sets from a variety of genomic
assays using a novel computational pipeline to provide a global view of estrogen receptor 1 …
assays using a novel computational pipeline to provide a global view of estrogen receptor 1 …
The estrogen-regulated transcriptome: rapid, robust, extensive, and transient
YM Vasquez, WL Kraus - … Receptor and Breast Cancer: Celebrating the …, 2019 - Springer
The steroid hormone estrogen has potent effects in a variety of tissues across the body in
both females and males. In the nuclear signaling pathway for estrogens, the hormone acts …
both females and males. In the nuclear signaling pathway for estrogens, the hormone acts …
Genome-wide estrogen receptor activity in breast cancer
AM Farcas, S Nagarajan, S Cosulich, JS Carroll - Endocrinology, 2021 - academic.oup.com
The largest subtype of breast cancer is characterized by the expression and activity of the
estrogen receptor alpha (ERalpha/ER). Although several effective therapies have …
estrogen receptor alpha (ERalpha/ER). Although several effective therapies have …
Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-α responsive promoters
In breast cancer and normal estrogen target tissues, estrogen receptor-α (ERα) signaling
results in the establishment of spatiotemporal patterns of gene expression. Whereas primary …
results in the establishment of spatiotemporal patterns of gene expression. Whereas primary …
[PDF][PDF] Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor
KX Rosenfeld - academia.edu
The function of enhancer RNAs (eRNAs) in transcriptional regulation remains obscure. By
analyzing the genome-wide nascent transcript profiles in breast cancer cells, we identify a …
analyzing the genome-wide nascent transcript profiles in breast cancer cells, we identify a …
Differential recruitment of nuclear receptor coregulators in ligand-dependent transcriptional repression by estrogen receptor-α
KW Merrell, JD Crofts, RL Smith, JH Sin, KE Kmetzsch… - Oncogene, 2011 - nature.com
Estrogen receptors (ERs) are normally expressed in breast tissues and mediate hormonal
functions during development and in female reproductive physiology. In the majority of …
functions during development and in female reproductive physiology. In the majority of …
Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization
Background The estrogen receptor (ER) is a ligand-dependant transcription factor
expressed in many breast cancers and is the target of many endocrine-based cancer …
expressed in many breast cancers and is the target of many endocrine-based cancer …
Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators
Z Madak‐Erdogan, TH Charn, Y Jiang… - Molecular systems …, 2013 - embopress.org
The closely related transcription factors (TFs), estrogen receptors ERα and ERβ, regulate
divergent gene expression programs and proliferative outcomes in breast cancer. Utilizing …
divergent gene expression programs and proliferative outcomes in breast cancer. Utilizing …
Enhancer RNAs mediate estrogen-induced decommissioning of selective enhancers by recruiting ERα and its cofactor
The function of enhancer RNAs (eRNAs) in transcriptional regulation remains obscure. By
analyzing the genome-wide nascent transcript profiles in breast cancer cells, we identify a …
analyzing the genome-wide nascent transcript profiles in breast cancer cells, we identify a …