Aims: To determine the relation between lower airway infection and inflammation,
respiratory symptoms, and lung function in infants and young children with cystic fibrosis …

Our aim was to study the effect of lower airway infection on clinical parameters, pulmonary
function tests, and inflammation in clinically stable infants and young children with cystic …

Airway inflammation is an important component of cystic fibrosis (CF) lung disease. To
determine whether this begins early in the illness, before the onset of infection, we examined …

Controversy exists over whether the lower airway inflammation that characterizes cystic
fibrosis (CF) is initiated primarily by the genetic defect. To determine if inflammation …

Rationale: Progressive lung damage in cystic fibrosis (CF) starts in infancy, and early
detection may aid preventative strategies. Objectives: To measure lung function in infants …

Rationale: Better understanding of evolution of lung function in infants with cystic fibrosis
(CF) and its association with pulmonary inflammation and infection is crucial in informing …

This study aimed to investigate the evolution of airway function in infants newly diagnosed
with cystic fibrosis (CF). FEV0. 5 was measured soon after diagnosis (median age of 28 …

Rationale: Pulmonary inflammation, infection, and structural lung disease occur early in life
in children with cystic fibrosis. Objectives: We hypothesized that the presence of these …

A thorough understanding of the early natural history of cystic fibrosis (CF) lung disease is
critical for the development of effective interventions in the youngest patients. We assessed …

Rationale: After recent standardization of forced expiratory maneuvers for both infants and
preschool children, longitudinal measurements are now possible from birth. Objectives: The …