Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility
Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD
Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …
[HTML][HTML] Emerging methods and resources for biological interrogation of neuropsychiatric polygenic signal
E Uffelmann, D Posthuma - Biological Psychiatry, 2021 - Elsevier
Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of
causal genetic variants that span much of the genome. This widespread polygenicity …
causal genetic variants that span much of the genome. This widespread polygenicity …
Varying intolerance of gene pathways to mutational classes explain genetic convergence across neuropsychiatric disorders
Genetic susceptibility to intellectual disability (ID), autism spectrum disorder (ASD), and
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …
Single-cell analysis of prenatal and postnatal human cortical development
D Velmeshev, Y Perez, Z Yan, JE Valencia… - Science, 2023 - science.org
We analyzed> 700,000 single-nucleus RNA sequencing profiles from 106 donors during
prenatal and postnatal developmental stages and identified lineage-specific programs that …
prenatal and postnatal developmental stages and identified lineage-specific programs that …
Phenomics: the systematic study of phenotypes on a genome-wide scale
Phenomics is an emerging transdiscipline dedicated to the systematic study of phenotypes
on a genome-wide scale. New methods for high-throughput genotyping have changed the …
on a genome-wide scale. New methods for high-throughput genotyping have changed the …
Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice
JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
A shared neural basis underlying psychiatric comorbidity
Recent studies proposed a general psychopathology factor underlying common
comorbidities among psychiatric disorders. However, its neurobiological mechanisms and …
comorbidities among psychiatric disorders. However, its neurobiological mechanisms and …
Genome-scale neurogenetics: methodology and meaning
Genetic analysis is currently offering glimpses into molecular mechanisms underlying such
neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of …
neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of …
The road to precision psychiatry: translating genetics into disease mechanisms
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …