Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …

Effective treatment for schizophrenia is still an unmet clinical need. Alleviating problems
associated with cognitive impairment and finding the root of the disease remain priorities for …

Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …

The development and function of our brain are governed by a genetic blueprint, which
reflects dynamic changes over the history of evolution. Recent progress in genetics and …

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …

INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

Neurogenetics research has begun to advance our understanding of how genetic variation
gives rise to individual differences in brain function, which, in turn, shapes behavior and risk …

Recent advances in identifying risk-associated genes have provided unprecedented
opportunities for developing animal models for psychiatric disease research with the goal of …

Understanding which biological pathways are specific versus general across diagnostic
categories and levels of symptom severity is critical to improving nosology and treatment of …