INTRODUCTION Chromosomal conformations, topologically associated chromatin domains
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …

Mutations in gene regulatory elements have been associated with a wide range of complex
neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in …

There is mounting evidence that seemingly diverse psychiatric disorders share genetic
etiology, but the biological substrates mediating this overlap are not well characterized. Here …

Psychiatry is undergoing a paradigm shift from the acceptance of distinct diagnoses to a
representation of psychiatric illness that crosses diagnostic boundaries. How this transition …

Neuroimaging genomic studies of autism spectrum disorder and schizophrenia have mainly
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …

Editorial summary Breakthroughs on many fronts have provided strong evidence to support
synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have …

Although gene discovery in neuropsychiatric disorders, including autism spectrum disorder,
intellectual disability, epilepsy, schizophrenia, and Tourette disorder, has accelerated …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …

The primary aim of precision medicine is to tailor healthcare more closely to the needs of
individual patients. This requires progress in two areas: the development of more precise …