Pathogenesis of Parkinson's disease: prospects of neuroprotective and restorative therapies

E Fernandez-Espejo - Molecular neurobiology, 2004 - Springer
Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of
substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most …

Emerging restorative treatments for Parkinson's disease

T Deierborg, D Soulet, L Roybon, V Hall… - Progress in …, 2008 - Elsevier
Several exciting approaches for restorative therapy in Parkinson's disease have emerged
over the past two decades. This review initially describes experimental and clinical data …

Neuroprotective therapy in Parkinson disease

S Chen, W Le - American journal of therapeutics, 2006 - journals.lww.com
During the past decade, there has been a remarkable progress in our understanding of the
biology of Parkinson disease (PD), which has been translated into searching for novel …

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat …

M Levivier, S Przedborski, C Bencsics… - Journal of …, 1995 - Soc Neuroscience
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive
loss of the dopaminergic neurons of the substantia nigra pars compacta (SNpc). Although …

Encapsulated cell biodelivery of GDNF: a novel clinical strategy for neuroprotection and neuroregeneration in Parkinson's disease?

O Lindvall, LU Wahlberg - Experimental neurology, 2008 - Elsevier
The main pathology underlying disease symptoms in Parkinson's disease (PD) is a
progressive degeneration of nigrostriatal dopamine (DA) neurons. No effective disease …

Functional regeneration in a rat Parkinson's model after intrastriatal grafts of glial cell line-derived neurotrophic factor and transforming growth factor β1-expressing …

EF Espejo, MC Gonzalez-Albo, JP Moraes… - Journal of …, 2001 - Soc Neuroscience
Intrabrain transplantation of chromaffin cell aggregates of the Zuckerkandl9s organ, an extra-
adrenal paraganglion that has never been tested for antiparkinsonian treatment, induced …

[HTML][HTML] Combined cell-based therapy strategies for the treatment of Parkinson's disease: focus on mesenchymal stromal cells

J Rodríguez-Pallares, M García-Garrote… - Neural Regeneration …, 2023 - journals.lww.com
Parkinson's disease is a neurodegenerative condition characterized by motor impairments
caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is …

Neuroprotection in Parkinson's disease: an elusive goal

WC Koller, MG Cersosimo - Current neurology and neuroscience reports, 2004 - Springer
Parkinson's disease is a chronic progressive condition that causes disability and reduction
of quality of life. Symptomatic treatments are effective in the early disease; however, with …

Intracerebral transplantation of genetically engineered cells for Parkinson's disease: toward clinical application

T Yasuhara, I Date - Cell transplantation, 2007 - journals.sagepub.com
Over the last decade, molecular biology has progressively developed, leading to new
technology with subsequent clinical application for various cerebral diseases including …

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in …

A Björklund, D Kirik, C Rosenblad, B Georgievska… - Brain research, 2000 - Elsevier
During the last few years, recombinant viral vectors derived from adenovirus (Ad), adeno-
associated virus (AAV) or lentivirus (LV) have been developed into highly effective vehicles …