Natural products, including botanical dietary supplements and exotic drinks, represent an
ever‐increasing share of the health‐care market. The parallel ever‐increasing popularity of …

We aimed to explore the major active components in grapefruit juice (GFJ), orange juice
(OJ), and apple juice (AJ) that are responsible for OATP2B1‐mediated drug interactions, by …

Grapefruit juice is widely recognized to cause important drug interactions via inhibition of
CYP3A4, and a wider variety of fruit juices have been shown to inhibit influx transporters in …

Dietary substances, including herbal products and citrus juices, can perpetrate interactions
with conventional medications. Regulatory guidances for dietary substance–drug interaction …

The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …

The effect of food on pharmacokinetic properties of drugs is a commonly observed
occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical …

Natural products have been used by humans since antiquity for both egregious and
beneficial purposes. Regarding the latter, these products have long been valued as a rich …

Recently there has been speculation regarding prescription drug interactions with fruit
beverages through inhibition of drug uptake transport by organic anion transporter …

Food additives are compounds that are added to food and beverage to improve the taste,
color, preservation, or composition. Generally, food additives are considered safe for human …

Food can alter the absorption of orally administered drugs. Biopharmaceutics
physiologically based pharmacokinetic (PBPK) modeling offers the possibility to simulate a …