[HTML][HTML] Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala

F Sotres-Bayon, DEA Bush, JE LeDoux - Neuropsychopharmacology, 2007 - nature.com
N-methyl-D-aspartate receptors (NMDARs) contribute to synaptic plasticity underlying
learning in a variety of brain systems. Fear extinction, which involves learning to suppress …

Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution

F Sotres-Bayon, L Diaz-Mataix, DEA Bush… - Cerebral …, 2009 - academic.oup.com
Fear extinction, which involves learning to suppress the expression of previously learned
fear, requires N-methyl-D-aspartate receptors (NMDARs) and is mediated by the amygdala …

The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear

V Laurent, AR Marchand, RF Westbrook - Learning & memory, 2008 - learnmem.cshlp.org
Extinction of conditioned fear involves new learning that inhibits but does not eliminate the
original fear memory. This inhibitory learning is thought to require activation of NMDA …

NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory

F Zinebi, J Xie, J Liu, RT Russell… - Journal of …, 2003 - Soc Neuroscience
The amygdala plays a critical role in fear conditioning, a model of emotional learning and
cue-induced anxiety. In the lateral amygdala, fear conditioning is associated with an …

NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala

KA Goosens, S Maren - European Journal of Neuroscience, 2004 - Wiley Online Library
We examined the contribution of N‐methyl‐d‐aspartate (NMDA) receptors (NMDARs) to the
acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using …

Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning

SM Rodrigues, GE Schafe, JE LeDoux - Journal of neuroscience, 2001 - Soc Neuroscience
The lateral nucleus of the amygdala (LA) is an essential component of the neural circuitry
underlying Pavlovian fear conditioning. Although blockade of NMDA receptors in LA and …

Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear …

DL Walker, M Davis - Learning & Memory, 2008 - learnmem.cshlp.org
Within the amygdala, most N-methyl-D-aspartic acid (NMDA) receptors consist of NR1
subunits in combination with either NR2A or NR2B subunits. Because the particular subunit …

[HTML][HTML] Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex

A Burgos-Robles, I Vidal-Gonzalez, E Santini, GJ Quirk - Neuron, 2007 - cell.com
Extinction of conditioned fear is an active learning process requiring N-methyl-D-aspartate
receptors (NMDARs), but the timing, location, and neural mechanisms of NMDAR-mediated …

Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats

H Lee, JJ Kim - Journal of Neuroscience, 1998 - Soc Neuroscience
NMDA receptors in the amygdala seem to be critical for fear conditioning in naive rats.
Recent spatial-learning studies suggest that previous learning protected animals from the …

[HTML][HTML] Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level

Y Li, S Sacchi, L Pollegioni, AC Basu, JT Coyle… - Nature …, 2013 - nature.com
Mechanisms of N-methyl-d-aspartate receptor-dependent synaptic plasticity contribute to the
acquisition and retention of conditioned fear memory. However, synaptic rules which may …