Cilia and mitotic spindles are microtubule (MT)-based, macromolecular machines that
consecutively assemble and disassemble during interphase and M phase of the cell cycle …

Microtubule‐based motor proteins play key roles during mitosis to assemble the bipolar
spindle, define the cell division axis, and align and segregate the chromosomes. The …

Kinesins are enzymes that use the energy of ATP to perform mechanical work. There are
approximately 14 families of kinesins within the kinesin superfamily. Family classification is …

The interplay between microtubules and microtubule-based motors is fundamental to basic
aspects of cellular function, such as the intracellular transport of organelles and alterations …

Motility is a hallmark of life. Even cells that are incapable of active movement within their
environment perform essential intracellular motility processes. A number of mechanisms …

During mitosis, the mitotic spindle is assembled to align chromosomes at the spindle
equator in metaphase, and to separate the genetic material equally to daughter cells in …

Accurate segregation of genetic material during both mitosis and meiosis is essential for the
viability of future cellular generations. Genetic material is packaged in the form of …

Defects in ciliary assembly, maintenance, and signaling are associated with various human
diseases and developmental disorders, termed ciliopathies. Eukaryotic flagella and cilia …

The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from
providing tracks for intracellular transport, to supporting movement of cilia and flagella, to …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …