After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …

Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Background Single-cell sequencing technologies have advanced our understanding of
kidney biology and disease, but the loss of spatial information in these datasets hinders our …

Though an acute kidney injury (AKI) episode is associated with an increased risk of chronic
kidney disease (CKD), the mechanisms determining the transition from acute to irreversible …

Renal tubular epithelial cells (TECs) can initiate an adaptive response to completely recover
from mild acute kidney injury (AKI), whereas severe injury often leads to persistence of …

Background Proximal tubule injury can initiate CKD, with progression rates that are
approximately 50% faster in males versus females. The precise transcriptional changes in …

Background Little is known about the roles of myeloid cell subsets in kidney injury and in the
limited ability of the organ to repair itself. Characterizing these cells based only on surface …

Acute kidney injury (AKI) is a major health issue, the outcome of which depends primarily on
damage and reparative processes of tubular epithelial cells. Mechanisms underlying AKI …