Acute renal failure (ARF) necessitating renal replacement therapy is a common problem
associated with high morbidity and mortality in the critically ill. Hypotension, followed by …

Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK 1 cells result in
phosphorylation of FKHR and FKHRL1. Background Cell death and survival pathways are …

Ischemia/reperfusion-induced acute renal failure is a common clinical problem associated
with a high morbidity and mortality. Upon hypoxic injury, the depletion of ATP causes …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

The mechanisms leading to the recovery of the kidney after ischemic acute renal failure are
poorly understood. To explore the role played by mitogenesis and dedifferentiation in this …

Microvascular endothelial injury and dysfunction during ischemic acute renal failure. The
pathophysiology of ischemic acute renal failure (ARF) appears to involve a complex …

The ischemically injured kidney undergoes tubular cell necrosis and apoptosis,
accompanied by an interstitial inflammatory cell infiltrate. In this study, we show that iNos …

C5b-9-induced glomerular epithelial cell (GEC) injury in vivo (in passive Heymann nephritis)
and in culture is associated with damage to the endoplasmic reticulum (ER) and increased …

The role of EGF in the evolution of renal lesions after injury is still controversial. To
determine whether the EGF expression is beneficial or detrimental, we generated transgenic …