The functional state of the preexisting T cells in the tumor microenvironment is a key
determinant for effective antitumor immunity and immunotherapy. Increasing evidence …

The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …

The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in
the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to …

Simple Summary Immunotherapies harness the hosts' immune system to combat cancer and
are currently used to treat many tumor types. Immunotherapies mainly target T cells, the …

Background Current immunotherapies still have limited successful rates among cancers. It is
now recognized that T cell functional state in the tumor microenvironment (TME) is a key …

Human tumors progress despite the presence of tumor associated antigen (TAA)-specific T
cells. Many different molecular and cellular mechanisms contribute to the failure of T cells to …

Senescent and suppressor T cells are reported to be increased in select patients with cancer
and are poor prognostic indicators. Based on the association of these T cells and poor …

Senescent cells as thermostats of antitumor immunity | Science Translational Medicine news
careers commentary Journals Science Science brought to you byGoogle Indexer Log in science …

Simple Summary Despite tremendous treatment efforts, cancer is still one of the leading
causes of death, with approximately 10 million deaths in 2020. In the last decade …

Immunotherapies have revolutionized cancer treatment, but despite the many lives that have
been extended by these therapies many patients do not respond for reasons that are not …