Cases of inflammatory bowel disease (IBD), a debilitating intestinal disorder with complex
pathological mechanisms, have been increasing in recent years, straining the capacity of …

Inflammasomes are multiprotein intracellular complexes which are responsible for the
activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 …

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and
small intestine, comprised of ulcerative colitis and Crohn's disease. Among the complicated …

The incidence and prevalence of inflammatory bowel disease (IBD) are increasing
worldwide. Current approved medication for IBD treatment in the clinic mainly includes …

NLRP3 inflammasome can be widely found in epithelial cells and immune cells. The NOD-
like receptors (NLRs) family member NLRP3 contains a central nucleotide-binding and …

Nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing
protein 3 (NLRP3) inflammasome is pivotal in maintaining intestinal homeostasis and …

Several lines of evidence point out the relevance of nucleotide-binding oligomerization
domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome …

Digestive system diseases remain a formidable challenge to human health. NOD-like
receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most characteristic …

Inflammasomes are multiprotein complexes formed to regulate the maturation of pro-
inflammatory caspases, in response to intracellular or extracellular stimulants. Accumulating …

Inflammatory bowel disease (IBD), mainly including Crohn's disease and ulcerative colitis,
seriously affects human health and causes substantial social and economic burden. The …