Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma …

T Butler, L Zhou, I Ozsahin, XH Wang… - Brain …, 2023 - academic.oup.com
The glymphatic system is a perivascular fluid clearance system, most active during sleep,
considered important for clearing the brain of waste products and toxins. Glymphatic failure …

Glymphatic system evaluation using diffusion tensor imaging in patients with traumatic brain injury

JH Park, YJ Bae, JS Kim, WS Jung, JW Choi, TH Roh… - Neuroradiology, 2023 - Springer
Purpose Glymphatic system dysfunction has been reported in animal models of traumatic
brain injury (TBI). This study aimed to evaluate the activity of the human glymphatic system …

The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …

Associations of MRI‐derived glymphatic system impairment with global white matter damage and cognitive impairment in mild traumatic brain injury: a DTI‐ALPS study

DX Yang, Z Sun, MM Yu, QQ Zou, PY Li… - Journal of Magnetic …, 2024 - Wiley Online Library
Background Assessing the glymphatic function using diffusion tensor image analysis along
the perivascular space (DTI‐ALPS) may be helpful for mild traumatic brain injury (mTBI) …

[HTML][HTML] Interaction between blood-brain barrier and glymphatic system in solute clearance

ICM Verheggen, MPJ Van Boxtel, FRJ Verhey… - Neuroscience & …, 2018 - Elsevier
Neurovascular pathology concurs with protein accumulation, as the brain vasculature is
important for waste clearance. Interstitial solutes, such as amyloid-β, were previously …

Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI

IF Harrison, B Siow, AB Akilo, PG Evans, O Ismail… - Elife, 2018 - elifesciences.org
The glymphatics system describes a CSF-mediated clearance pathway for the removal of
potentially harmful molecules, such as amyloid beta, from the brain. As such, its components …

Magnetic resonance imaging and modeling of the glymphatic system

J Kaur, E Davoodi-Bojd, LM Fahmy, L Zhang, G Ding… - Diagnostics, 2020 - mdpi.com
The glymphatic system is a newly discovered waste drainage pathway in the brain; it plays
an important role in many neurological diseases. Ongoing research utilizing various …

Assessment of the DTI‐ALPS parameter along the perivascular space in older adults at risk of dementia

CE Steward, VK Venkatraman, E Lui… - Journal of …, 2021 - Wiley Online Library
ABSTRACT BACKGROUND AND PURPOSE Recently, there has been growing interest in
the glymphatic system (the functional waste clearance pathway for the central nervous …

Increased glymphatic system activity in patients with mild traumatic brain injury

Z Dai, Z Yang, Z Li, M Li, H Sun, Z Zhuang… - Frontiers in …, 2023 - frontiersin.org
Purpose This study aims to investigate the glymphatic system activity changes in patients
with mild traumatic brain injury (mTBI), particularly in MRI-negative patients, using analysis …

Impaired glymphatic transport kinetics following induced acute ischemic brain edema in a mouse pMCAO model

J Zhang, H Zhao, Y Xue, Y Liu, G Fan, H Wang… - Frontiers in …, 2022 - frontiersin.org
Background Cerebral edema forms immediately after blood flow interruption in ischemic
stroke, which largely increased the death and disability. The glymphatic (glial-lymphatic) …