The skeleton is subject to dynamic changes throughout life and bone remodeling is
essential for maintenance of bone functionality. The cell populations which predominantly …

The skeleton has the ability to perfectly adapt to external forces of the operating
environment, by altering its morphology and metabolism in order to meet different needs …

This chapter reviews the state of knowledge with respect to skeletal mechanobiology. Forms
of tissue-level mechanical stimulation are first described, including electromagnetic fields …

Mechanical stimulation has a critical role in the development and maintenance of the
skeleton. This function requires the perception of extracellular stimuli as well as their …

Significance: Mechanosignaling is vital for maintaining the structural integrity of bone under
physiologic conditions. These signals activate and suppress multiple signaling cascades …

Osteoblasts are key components of the bone multicellular unit and have a seminal role in
bone remodeling, which is an essential function for the maintenance of the structural …

Bones are constantly exposed to mechanical forces from both muscles and Earth's gravity to
maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms …

Bone demonstrates a remarkable ability to renew itself, adapt its architecture, and repair
fractures to maintain strength throughout life. Mechanobiology, the study of how external …

Skeletal loading is an important physiological regulator of bone mass. Theoretically,
mechanical forces or administration of drugs that activate bone mechanosensors would be a …

Mechanotransduction is the process by which physical forces are converted into
biochemical signals that are then integrated into cellular responses. It plays a crucial role in …