U-statistics in genetic association studies

H Li - Human genetics, 2012 - Springer
Many common human diseases are complex and are expected to be highly heterogeneous,
with multiple causative loci and multiple rare and common variants at some of the causative …

Unrecognized sequence homologies may confound genome-wide association studies

P Galichon, L Mesnard, A Hertig, B Stengel… - Nucleic acids …, 2012 - academic.oup.com
Genome-wide association studies (GWAS) have become a preferred method to identify new
genetic susceptibility loci. This technique aims to understanding the molecular etiology of …

[HTML][HTML] Ubiquitous polygenicity of human complex traits: genome-wide analysis of 49 traits in Koreans

J Yang, T Lee, J Kim, MC Cho, BG Han, JY Lee… - PLoS …, 2013 - journals.plos.org
Recent studies in population of European ancestry have shown that 30%∼ 50% of
heritability for human complex traits such as height and body mass index, and common …

[HTML][HTML] Worldwide population differentiation at disease-associated SNPs

S Myles, D Davison, J Barrett, M Stoneking… - BMC medical …, 2008 - Springer
Background Recent genome-wide association (GWA) studies have provided compelling
evidence of association between genetic variants and common complex diseases. These …

[PDF][PDF] Genome-wide study on 72,298 individuals in Korean biobank data for 76 traits

K Nam, J Kim, S Lee - Cell Genomics, 2022 - cell.com
Genome-wide association studies (GWAS) on diverse ancestry groups are lacking, resulting
in deficits of genetic discoveries and polygenic scores. We conducted GWAS for 76 …

[HTML][HTML] Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study

IM Nolte, PJ Van Der Most, BZ Alizadeh… - European Journal of …, 2017 - nature.com
Despite the recent explosive rise in number of genetic markers for complex disease traits
identified in genome-wide association studies, there is still a large gap between the known …

The impact of improved microarray coverage and larger sample sizes on future genome‐wide association studies

KJ Lindquist, E Jorgenson, TJ Hoffmann… - Genetic …, 2013 - Wiley Online Library
Genome‐wide association studies (GWAS) have identified many single nucleotide
polymorphisms (SNP s) associated with complex traits. However, the genetic heritability of …

[HTML][HTML] GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies

T Beck, RK Hastings, S Gollapudi, RC Free… - European journal of …, 2014 - nature.com
To facilitate broad and convenient integrative visualization of and access to GWAS data, we
have created the GWAS Central resource (http://www. gwascentral. org). This database …

[HTML][HTML] Genome-wide association database developed in the Japanese Integrated Database Project

A Koike, N Nishida, I Inoue, S Tsuji… - Journal of human …, 2009 - nature.com
The establishment of high-throughput single-nucleotide polymorphism (SNP)-typing
technologies has enabled astonishing progress to be made in genome-wide association …

[HTML][HTML] Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Y Wang, J Guo, G Ni, J Yang, PM Visscher… - Nature …, 2020 - nature.com
Polygenic scores (PGS) have been widely used to predict disease risk using variants
identified from genome-wide association studies (GWAS). To date, most GWAS have been …