Glutamate neurons within the midbrain dopamine regions

M Morales, DH Root - Neuroscience, 2014 - Elsevier
Midbrain dopamine systems play important roles in Parkinson's disease, schizophrenia,
addiction, and depression. The participation of midbrain dopamine systems in diverse …

Ventral tegmental area glutamate neurons: electrophysiological properties and projections

TS Hnasko, GO Hjelmstad, HL Fields… - Journal of …, 2012 - Soc Neuroscience
The ventral tegmental area (VTA) has a central role in the neural processes that underlie
motivation and behavioral reinforcement. Although thought to contain only dopamine and …

Glutamate synaptic inputs to ventral tegmental area neurons in the rat derive primarily from subcortical sources

N Omelchenko, SR Sesack - Neuroscience, 2007 - Elsevier
Dopamine and GABA neurons in the ventral tegmental area project to the nucleus
accumbens and prefrontal cortex and modulate locomotor and reward behaviors as well as …

Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area

T Yamaguchi, J Qi, HL Wang, S Zhang… - European Journal of …, 2015 - Wiley Online Library
The ventral tegmental area (VTA) comprises dopamine (DA), γ‐aminobutyric acid (GABA)
and glutamate (Glu) neurons. Some rat VTA Glu neurons, expressing vesicular glutamate …

VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation

C Birgner, K Nordenankar… - Proceedings of the …, 2010 - National Acad Sciences
The “One neuron-one neurotransmitter” concept has been challenged frequently during the
last three decades, and the coexistence of neurotransmitters in individual neurons is now …

Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans

DH Root, HL Wang, B Liu, DJ Barker, L Mód… - Scientific reports, 2016 - nature.com
The rodent ventral tegmental area (VTA) and substantia nigra pars compacta (SNC) contain
dopamine neurons intermixed with glutamate neurons (expressing vesicular glutamate …

Dopamine neurons in culture express VGLUT2 explaining their capacity to release glutamate at synapses in addition to dopamine

G Dal Bo, F St‐Gelais, M Danik… - Journal of …, 2004 - Wiley Online Library
Dopamine neurons have been suggested to use glutamate as a cotransmitter. To identify the
basis of such a phenotype, we have examined the expression of the three recently identified …

Mesocorticolimbic glutamatergic pathway

T Yamaguchi, HL Wang, X Li, TH Ng… - Journal of …, 2011 - Soc Neuroscience
The mesocorticolimbic dopamine (DA) system plays important roles in reward, motivation,
learning, memory, and movement. This system arises from the A10 region, comprising the …

Glutamatergic neurons are present in the rat ventral tegmental area

T Yamaguchi, W Sheen… - European Journal of …, 2007 - Wiley Online Library
The ventral tegmental area (VTA) is thought to play an important role in reward function. Two
populations of neurons, containing either dopamine (DA) or γ‐amino butyric acid (GABA) …

Particular subpopulations of midbrain and hypothalamic dopamine neurons express vesicular glutamate transporter 2 in the rat brain

M Kawano, A Kawasaki, H Sakata‐Haga… - Journal of …, 2006 - Wiley Online Library
Abstract Vesicular glutamate transporters (VGLUT1,‐2, and‐3) mediate the accumulation of
transmitter glutamate into synaptic vesicles in glutamatergic neurons. VGLUT1 and VGLUT2 …