[HTML][HTML] SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the 'culprit lesion'of ARDS onset? What is there besides Tocilizumab? SGP130Fc

G Magro - Cytokine: X, 2020 - Elsevier
Since the outbreak of COVID-19 many studies have been published showing possible
therapies, here the author discusses the end of stage disease related drugs, like …

COVID-19 treatment: close to a cure? A rapid review of pharmacotherapies for the novel coronavirus (SARS-CoV-2)

Y Song, M Zhang, L Yin, K Wang, Y Zhou… - International journal of …, 2020 - Elsevier
Currently, there is no approved therapy for coronavirus disease 2019 (COVID-19). The
World Health Organization (WHO) therefore endorses supportive care only. However …

Old and re-purposed drugs for the treatment of COVID-19

SS Jean, PR Hsueh - Expert review of anti-infective therapy, 2020 - Taylor & Francis
Introduction: The coronavirus disease 2019 (COVID-19) caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed since December 2019. It …

IL‐18 and infections: Is there a role for targeted therapies?

A Vecchie, A Bonaventura, S Toldo… - Journal of cellular …, 2021 - Wiley Online Library
Abstract Interleukin (IL)‐18 is a pro‐inflammatory cytokine belonging to the IL‐1 family, first
identified for its interferon‐γ‐inducing properties. IL‐18 regulates both T helper (Th) 1 and …

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Y Jamilloux, T Henry, A Belot, S Viel, M Fauter… - Autoimmunity …, 2020 - Elsevier
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 …

Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context

F Angriman, BL Ferreyro, L Burry, E Fan… - The lancet respiratory …, 2021 - thelancet.com
The pleiotropic cytokine interleukin-6 (IL-6) has been implicated in the pathogenesis of
COVID-19, but uncertainty remains about the potential benefits and harms of targeting IL-6 …

[PDF][PDF] Cytokine-targeted therapy in severely ill COVID-19 patients: options and cautions

M Rahmati, MA Moosavi - mortality, 2020 - researchgate.net
Dear Editor, Coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV-2) with the symptoms …

Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia

A Vitiello, F Ferrara, C Pelliccia, G Granata… - Italian Journal of …, 2020 - italjmed.org
For some patients with SARS-CoV-2, the worst clinical damage is not caused by the virus
itself, but by an overactive inflammatory state. In fact, in some people the immune system …

[HTML][HTML] Current treatment in COVID-19 disease: a rapid review

M Rodriguez-Guerra, P Jadhav, TJ Vittorio - Drugs in context, 2021 - ncbi.nlm.nih.gov
The world has faced the most challenging pandemic of the modern era, that of severe acute
respiratory syndrome coronavirus 2 infection, causing coronavirus disease and affecting …