[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19

JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …

[HTML][HTML] Current treatment in COVID-19 disease: a rapid review

M Rodriguez-Guerra, P Jadhav, TJ Vittorio - Drugs in context, 2021 - ncbi.nlm.nih.gov
The world has faced the most challenging pandemic of the modern era, that of severe acute
respiratory syndrome coronavirus 2 infection, causing coronavirus disease and affecting …

Higher levels of IL‐6 early after tocilizumab distinguish survivors from nonsurvivors in COVID‐19 pneumonia: A possible indication for deeper targeting of IL‐6

L Quartuccio, A Sonaglia, D Pecori… - Journal of medical …, 2020 - Wiley Online Library
Introduction The most serious COVID‐19 deriving from severe acute respiratory syndrome
coronavirus 2 causes a cytokine release storm and it is associated with worse outcomes. In …

[HTML][HTML] A review of treatment of coronavirus disease 2019 (COVID-19): Therapeutic repurposing and unmet clinical needs

PL Chen, NY Lee, CT Cia, WC Ko… - Frontiers in …, 2020 - frontiersin.org
For the initial phase of pandemic of coronavirus disease 2019 (COVID-19), repurposing
drugs that in vitro inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …

Urgent avenues in the treatment of COVID-19: targeting downstream inflammation to prevent catastrophic syndrome

L Quartuccio, L Semerano, M Benucci, MC Boissier… - Joint bone spine, 2020 - Elsevier
At present, healthcare systems all over the world are coping with the new coronavirus
infection [1]. In particular, tremendous efforts are are being made in order to support …

[HTML][HTML] Associations between immune-suppressive and stimulating drugs and novel COVID-19—a systematic review of current evidence

B Russell, C Moss, G George, A Santaolalla… - …, 2020 - ncbi.nlm.nih.gov
Background Cancer and transplant patients with COVID-19 have a higher risk of developing
severe and even fatal respiratory diseases, especially as they may be treated with immune …

Immunity and inflammatory biomarkers in COVID‐19: a systematic review

APD Iwamura, MR Tavares da Silva… - Reviews in Medical …, 2021 - Wiley Online Library
Summary Coronavirus disease 2019 (COVID‐19) is a clinical syndrome caused by the
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus. Patients can be …

Effective treatment of severe COVID-19 patients with tocilizumab

X Xu, M Han, T Li, W Sun, D Wang… - Proceedings of the …, 2020 - National Acad Sciences
After analyzing the immune characteristics of patients with severe coronavirus disease 2019
(COVID-19), we have identified that pathogenic T cells and inflammatory monocytes with …

May IL-17 have a role in COVID-19 infection?

M Megna, M Napolitano, G Fabbrocini - Medical hypotheses, 2020 - ncbi.nlm.nih.gov
SARS-Corona-Virus-2 related disease (COVID-19) which started in Wuhan, China on
December 2019, is spreading rapidly throughout the world [1]. COVID-19 clinical spectrum is …

[HTML][HTML] A new approach to the management of COVID-19. Antagonists of IL-6: Siltuximab

L Villaescusa, F Zaragozá, I Gayo-Abeleira… - Advances in …, 2022 - Springer
Since the beginning of the pandemic, numerous national and international clinical trials
have been conducted with a large number of drugs. Many of them are intended for the …