Body fat distribution, particularly centralized obesity, is associated with metabolic risk above
and beyond total adiposity. We performed genome-wide association of abdominal adipose …

Background: To identify loci associated with abdominal fat and replicate prior findings, we
performed genome-wide association (GWA) studies of abdominal fat traits: subcutaneous …

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-
analysis of 16 genome-wide association studies (GWAS, N= 38,580) informative for adult …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Abdominal visceral fat (AVF), abdominal subcutaneous fat (ASF), and abdominal total fat
(ATF) were measured using a computed tomography scan, both before (baseline) and after …

Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To
identify common variants influencing central abdominal fat, we conducted a two-stage …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

For any given level of overall adiposity, individuals vary considerably in fat distribution. The
inherited basis of fat distribution in the general population is not fully understood. Here, we …

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker
of body fat distribution. Although obesity disproportionately affects minority populations, few …