Diastereoselective Synthesis of Functionalized Spirocyclopropyl Oxindoles via P(NMe2)3-Mediated Reductive Cyclopropanation

R Zhou, C Yang, Y Liu, R Li, Z He - The Journal of Organic …, 2014 - ACS Publications
AP (NMe2) 3-mediated reductive cyclopropanation reaction of α-keto esters or amides with
isatin-derived alkenes has been developed, providing efficient and diastereoselective …

Regio-and diastereoselective construction of spirocyclopenteneoxindoles through phosphine-catalyzed [3+ 2] annulation of methyleneindolinone with alkynoate …

J Zhang, C Cheng, D Wang, Z Miao - The Journal of Organic …, 2017 - ACS Publications
A phosphine-catalyzed [3+ 2] annulation of isatin-derived α, β-unsaturated ketones with
alkynoates for the synthesis of cyclopentene spiro-oxindole skeletons has been developed …

Lewis acid catalyzed annulation of spirocyclic donor–acceptor cyclopropanes with exo-heterocyclic olefins: access to highly functionalized bis-spirocyclopentane …

K Singh, S Pramanik, TA Hamlin, B Mondal… - Chemical …, 2019 - pubs.rsc.org
Lewis acid catalyzed highly efficient [3+ 2] annulation of spirocyclic Donor–Acceptor
cyclopropanes (DACs) with exo-heterocyclic olefins is reported to furnish various …

Catalytic asymmetric synthesis of polysubstituted spirocyclopropyl oxindoles: organocatalysis versus transition metal catalysis

ZY Cao, J Zhou - Organic Chemistry Frontiers, 2015 - pubs.rsc.org
Spirocyclopropyl oxindoles are widely present in natural products and bioactive molecules.
In addition, they play a significant role as a type of donor–acceptor (DA) cyclopropanes in …

Diastereoselective Synthesis of Cycloheptannelated Indoles via Lewis-Acid-Catalyzed (4+ 3)-Cyclization of Donor–Acceptor Cyclopropanes

BQ Li, ZW Qiu, AJ Ma, JB Peng, N Feng, JY Du… - Organic …, 2020 - ACS Publications
An efficient and straightforward Lewis-acid-mediated stereoselective (4+ 3)-cyclization of
indole-substituted alkylidene malonates and donor–acceptor cyclopropanes has been …

PPh3 Mediated Reductive Annulation Reaction between Isatins and Electron Deficient Dienes to Construct Spirooxindole Compounds

L Zhang, H Lu, GQ Xu, ZY Wang… - The Journal of Organic …, 2017 - ACS Publications
A PPh3 mediated reductive annulation reaction between isatins and 4, 4-dicyano-2-
methylenebut-3-enoates was developed. The reaction provided an alternative method for …

Stereochemical implications in the synthesis of 3, 3′-spirocyclopropyl oxindoles from β-aryl/alkyl-substituted alkylidene oxindoles

EE Wilson, KX Rodriguez, BL Ashfeld - Tetrahedron, 2015 - Elsevier
Spirocyclopropane oxindoles were synthesized in good to excellent yield and
diastereoselectivity employing a Kukhtin–Ramirez reaction between readily accessible E …

Rhodium-catalyzed sequential cycloisomerization/aldol addition of cyclopropene carboxylic acids with isatins

D Zhang, X Wang, M Zhang, W Hu - Organic Letters, 2020 - ACS Publications
A unique, rhodium-catalyzed reaction of cyclopropene carboxylic acids with isatins has been
developed, which takes place through a trapping process of transient cyclic carboxylic …

Dialkyl Phosphite-Initiated Cyclopropanation of α, β-Unsaturated Ketones Using α-Ketoesters or Isatin Derivatives

D Yin, H Liu, CD Lu, YJ Xu - The Journal of Organic Chemistry, 2017 - ACS Publications
Efficient cyclopropanation of α, β-unsaturated ketones using α-ketoesters or isatin
derivatives is reported. The cyclopropanation reaction occurs via a cascade transformation …

Metal-Free Directed Diastereoselective C2, C3-Cyclopropanation of Substituted Indoles with Diazoesters

J Ghorai, P Anbarasan - Organic letters, 2019 - ACS Publications
A metal-free directed C2, C3-cyclopropanation of suitably substituted indoles with α-diazo
esters has been accomplished for the diastereoselective synthesis of cyclopropane-fused …