Therapeutic implications of miRNAs for muscle-wasting conditions

L Yedigaryan, M Sampaolesi - Cells, 2021 - mdpi.com
MicroRNAs (miRNAs) are small, non-coding RNA molecules that are mainly involved in
translational repression by binding to specific messenger RNAs. Recently, miRNAs have …

MicroRNA dysregulation in aging and pathologies of the skeletal muscle

R McCormick, K Goljanek-Whysall - … Review of Cell and Molecular Biology, 2017 - Elsevier
Skeletal muscle is one of the biggest organs of the body with important mechanistic and
metabolic functions. Muscle homeostasis is controlled by environmental, genetic, and …

Tiny regulators of massive tissue: MicroRNAs in skeletal muscle development, myopathies, and cancer cachexia

GB Singh, DB Cowan, DZ Wang - Frontiers in oncology, 2020 - frontiersin.org
Skeletal muscles are the largest tissues in our body and the physiological function of muscle
is essential to every aspect of life. The regulation of development, homeostasis, and …

microRNAs: Modulators of the underlying pathophysiology of sarcopenia?

DM Brown, K Goljanek-Whysall - Ageing research reviews, 2015 - Elsevier
Skeletal muscle homeostasis depends on an intricate balance between muscle hypertrophy,
atrophy and regeneration. As we age, maintenance of muscle homeostasis is perturbed …

Role of microRNA in muscle regeneration and diseases related to muscle dysfunction in atrophy, cachexia, osteoporosis, and osteoarthritis

J Brzeszczyńska, F Brzeszczyński… - Bone & joint …, 2020 - boneandjoint.org.uk
MicroRNAs (miRNAs) are a class of small non-coding RNAs that have emerged as potential
predictive, prognostic, and therapeutic biomarkers, relevant to many pathophysiological …

MicroRNA regulatory networks in the pathogenesis of sarcopenia

J Yin, Z Qian, Y Chen, Y Li… - Journal of Cellular and …, 2020 - Wiley Online Library
Sarcopenia is an age‐related disease characterized by disturbed homeostasis of skeletal
muscle, leading to a decline in muscle mass and function. Loss of muscle mass and strength …

miRNAS in normal and diseased skeletal muscle

I Eisenberg, MS Alexander… - Journal of cellular and …, 2009 - Wiley Online Library
• Introduction• Mechanisms of miRNA‐mediated repression• miRNA regulatory network in
muscle‐Muscle‐specific miRNAs‐Non‐muscle‐specific miRNAs• miRNA signatures as …

MicroRNA in skeletal muscle development, growth, atrophy, and disease

A Kovanda, T Režen, B Rogelj - Wiley Interdisciplinary Reviews …, 2014 - Wiley Online Library
Micro RNAs (miRNAs) are short noncoding RNAs that are important global‐as well as tissue‐
and cell‐type‐specific regulators of gene expression. Muscle‐specific miRNAs or myomirs …

MicroRNAs in skeletal muscle: their role and regulation in development, disease and function

I Güller, AP Russell - The Journal of physiology, 2010 - Wiley Online Library
Maintaining skeletal muscle function throughout the lifespan is a prerequisite for good health
and independent living. For skeletal muscle to consistently function at optimal levels, the …

MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease

E Zacharewicz, S Lamon, AP Russell - Frontiers in physiology, 2013 - frontiersin.org
Skeletal muscle makes up approximately 40% of the total body mass, providing structural
support and enabling the body to maintain posture, to control motor movements and to store …