Animal models of typical heterotopic ossification

L Kan, JA Kessler - BioMed Research International, 2011 - Wiley Online Library
Heterotopic ossification (HO) is the formation of marrow‐containing bone outside of the
normal skeleton. Acquired HO following traumatic events is a common and costly clinical …

Heterotopic ossification: mechanistic insights and clinical challenges

R Xu, J Hu, X Zhou, Y Yang - Bone, 2018 - Elsevier
Bone formation is exquisitely controlled both spatially and temporally. Heterotopic
ossification (HO) is pathological bone formation in soft tissues that often leads to deleterious …

Heterotopic ossification: a comprehensive review

C Meyers, J Lisiecki, S Miller, A Levin, L Fayad… - JBMR …, 2019 - Wiley Online Library
Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of
extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair …

Characterization of cells isolated from genetic and trauma-induced heterotopic ossification

S Agarwal, J Drake, AT Qureshi, S Loder, S Li… - PLoS …, 2016 - journals.plos.org
Heterotopic ossification (HO) is the pathologic formation of bone separate from the normal
skeleton. Although several models exist for studying HO, an understanding of the common in …

Challenges of heterotopic ossification—molecular background and current treatment strategies

P Łęgosz, K Drela, Ł Pulik… - Clinical and …, 2018 - Wiley Online Library
Heterotopic ossification (HO) is an abnormal formation of mature lamellar bone within
extraskeletal soft tissues, such as muscles, tendons, and ligaments. This process is thought …

Stem cells and heterotopic ossification: lessons from animal models

JB Lees-Shepard, DJ Goldhamer - Bone, 2018 - Elsevier
Put most simply, heterotopic ossification (HO) is the abnormal formation of bone at
extraskeletal sites. HO can be classified into two main subtypes, genetic and acquired …

Pathogenesis of acquired heterotopic ossification: risk factors, cellular mechanisms, and therapeutic implications

G Cao, S Zhang, Y Wang, S Quan, C Yue, J Yao… - Bone, 2023 - Elsevier
Heterotopic ossification (HO), including hereditary and acquired HO, is the formation of
extraskeletal bone in skeletal muscle and surrounding soft tissues. Acquired HO is often …

Development of an animal model for traumatic brain injury augmentation of heterotopic ossification in response to local injury

C Kesavan, GA Gomez, S Pourteymoor, S Mohan - Biomedicines, 2023 - mdpi.com
Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that
occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare …

[PDF][PDF] Animal models for acquired heterotopic ossification

J Anthonissen, C Ossendorf, U Ritz… - Acta Orthop …, 2014 - actaorthopaedica.be
As there is still neither proper treatment nor reliable prophylaxis, animal models will remain
important in the study of HO. Currently, there are 6 different animal models regularly used for …

[PDF][PDF] Current review of heterotopic ossification

JE Hsu, MA Keenan - UPOJ, 2010 - upoj.org
Heterotopic ossification, the abnormal development of bone in areas of the body other than
skeletal tissue, commonly occurs in association with traumatic brain injury and spinal cord …