Emerging topical and systemic JAK inhibitors in dermatology
F Solimani, K Meier, K Ghoreschi - Frontiers in immunology, 2019 - frontiersin.org
Accumulating data on cellular and molecular pathways help to develop novel therapeutic
strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic …
strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic …
JAK inhibitors in dermatology: the promise of a new drug class
New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …
Targeting the Janus kinase family in autoimmune skin diseases
Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
Janus kinase inhibitors in dermatology: Part II. A comprehensive review
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular
signaling pathway is implicated in the pathogenesis of a number of inflammatory …
signaling pathway is implicated in the pathogenesis of a number of inflammatory …
[HTML][HTML] Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation
JS Fridman, PA Scherle, R Collins, T Burn… - Journal of Investigative …, 2011 - Elsevier
JAKs are required for signaling initiated by several cytokines (eg, IL-4, IL-12, IL-23, thymic
stromal lymphopoietin (TSLP), and IFNγ) implicated in the pathogenesis of inflammatory skin …
stromal lymphopoietin (TSLP), and IFNγ) implicated in the pathogenesis of inflammatory skin …
JAK inhibitors: Ten years after
Abstract The European Journal of Immunology was launched 50 years ago, coinciding with
the discovery of many cytokines and growth factors and the emergence of an entirely new …
the discovery of many cytokines and growth factors and the emergence of an entirely new …
JAK-inhibitors in dermatology: current evidence and future applications
P Ciechanowicz, A Rakowska, M Sikora… - Journal of …, 2019 - Taylor & Francis
The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway
is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti …
is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti …
Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors
K Welsch, J Holstein, A Laurence… - European journal of …, 2017 - Wiley Online Library
For most inflammatory skin diseases topical glucocorticosteroids and traditional oral
immunosuppressive drugs remain the principle treatment choices, but this has started to …
immunosuppressive drugs remain the principle treatment choices, but this has started to …
JAK3 as an emerging target for topical treatment of inflammatory skin diseases
AK Alves de Medeiros, R Speeckaert, E Desmet… - PLoS …, 2016 - journals.plos.org
The recent interest and elucidation of the JAK/STAT signaling pathway created new targets
for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical …
for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical …
JAK‐inhibitors in dermatology–small molecules, big impact? Overview of the mechanism of action, previous study results and potential adverse effects
B Klein, R Treudler, JC Simon - JDDG: Journal der Deutschen …, 2022 - Wiley Online Library
Numerous chronic inflammatory skin diseases are associated with the release of
proinflammatory cytokines, which act via the intracellular JAK‐STAT pathway. JAK inhibitors …
proinflammatory cytokines, which act via the intracellular JAK‐STAT pathway. JAK inhibitors …