Inflammation and JAK/STAT Signaling: New Clues for the Treatment of COVID-19

R Shirazinia, M Afshari, AA Golabchifar… - … Journal of Basic …, 2022 - ijbsm.zbmu.ac.ir
Abstract The coronavirus disease 19 (COVID-19) outbreak in Wuhan, Hubei province, is a
global health problem affecting about 212 countries around the world, highlighting the …

[HTML][HTML] COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy

M Khaledi, F Sameni, S Yahyazade… - Frontiers in …, 2022 - frontiersin.org
Recent evidence proposed that the severity of Coronavirus disease 2019 (COVID-19)
patients is a consequence of cytokine storm, characterized by increased IL-1β, IL-6, IL-18 …

JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …

[HTML][HTML] Systematic Review: JAK-STAT Regulation and Its Impact on Inflammation Response in ARDS from COVID-19

I Rodriguez, KJF Carnevale - Immuno, 2024 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has had a global
impact and resulted in millions of deaths worldwide. The course of the Janus kinase …

Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infection

F Solimani, K Meier, K Ghoreschi - European journal of …, 2021 - Wiley Online Library
Cytokine signaling, especially interferon (IFN) signaling is closely linked to several aspects
of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. During initial …

Targeting JAK-STAT signaling to control cytokine release syndrome in COVID-19

W Luo, YX Li, LJ Jiang, Q Chen, T Wang… - Trends in pharmacological …, 2020 - cell.com
Recent advances in the pathophysiologic understanding of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has indicated that patients with severe …

[PDF][PDF] for severe SARS-CoV-2 infection

F Solimani, K Meier, K Ghoreschi - researchgate.net
Cytokine signaling, especially interferon (IFN) signaling is closely linked to several aspects
of SARS-CoV-2 infection. During initial SARS-CoV-2 infection, symptomatic patients present …

[HTML][HTML] JAK inhibition as a new treatment strategy for patients with COVID-19

J Huang, C Zhou, J Deng, J Zhou - Biochemical Pharmacology, 2022 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic continues to
spread globally. The rapid dispersion of coronavirus disease 2019 (COVID-19) caused by …

Calming the cytokine storm of COVID-19 through inhibition of JAK2/STAT3 signaling

BK Gajjela, MM Zhou - Drug discovery today, 2022 - Elsevier
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused the unprecedented COVID-19 pandemic, which has infected over 178 million people …

Old drugs for jak-stat pathway inhibition in COVID-19

MR Dayer - arXiv preprint arXiv:2010.12332, 2020 - arxiv.org
The pandemic threat of COVID-19 with more than 37 million cases in which about 5 percent
entering critical stage characterized by cytokine storm and hyperinflammatory condition, the …