Protein products prepared from pooled human plasma are an essential class of therapeutics
used mostly to control bleeding and/or immunological disorders. Because of the human …

The emergence of the variant Creutzfeldt-Jakob disease in the mid 1990s soon raised
concerns about its possible transmission through the use of blood and plasma-derived …

Reports about transfusion-related transmissions of variant Creutzfeldt-Jakob disease have
urged the need for more information regarding the risk for prion contaminated units in the …

Transfusion of plasma can lead to adverse reactions or events. Immune-mediated reactions
are most common—these include allergic and anaphylactic reactions, transfusion-related …

The transmission of Creutzfeldt-Jakob disease (CJD) by human pituitary-derived growth
hormone has led to concerns that blood products might also provide a route for the …

Protein products isolated from human plasma are an important class of therapeutics that are
used to treat patients afflicted with hereditary deficiencies, trauma, and severe infections …

Various experimental studies have shown infectivity in blood in relation to bovine
spongiform encephalitis (BSE) and variant Creutzfeldt–Jakob disease (vCJD). Human to …

The evaluation of the removal efficacy during manufacturing is important for the risk
assessment of plasma products with respect to possible contamination by infectious prions …

Although there is no evidence that classical CJD (cCJD) can be transmitted by human blood
or blood products in clinical practice, uncertainties surrounding new variant CJD (nvCJD) …

Prions are not detectable in the blood or plasma of persons afflicted with classical or variant
Creutzfeldt-Jakob disease, and they have never been shown to be transmitted by blood or …