COVID‐19 immunopathology: from acute diseases to chronic sequelae

M Arish, W Qian, H Narasimhan… - Journal of medical …, 2023 - Wiley Online Library
The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …

Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19

NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …

The pathogenesis of coronavirus-19 disease

AC Borczuk, RK Yantiss - Journal of biomedical science, 2022 - Springer
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …

The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge

M Buszko, JH Park, D Verthelyi, R Sen, HA Young… - Nature …, 2020 - nature.com
“The role of cytokines in COVID-19” online symposium was presented on 18 June 2020 by
the NIH/FDA Immunology and Cytokine Interest Groups and was purposed to discuss our …

Innate immune signaling and proteolytic pathways in the resolution or exacerbation of SARS-CoV-2 in Covid-19: key therapeutic targets?

JM Sallenave, L Guillot - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-
2, an enveloped virus with a positive-polarity, single-stranded RNA genome. The initial …

Different innate and adaptive immune responses to SARS-CoV-2 infection of asymptomatic, mild, and severe cases

R Carsetti, S Zaffina, E Piano Mortari, S Terreri… - Frontiers in …, 2020 - frontiersin.org
SARS-CoV-2 is a novel coronavirus, not encountered before by humans. The wide spectrum
of clinical expression of SARS-CoV-2 illness suggests that individual immune responses to …

COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options

LE van Eijk, M Binkhorst, AR Bourgonje… - The Journal of …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), continues to spread globally despite the worldwide …

Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2

YH Chan, SW Fong, CM Poh, G Carissimo… - EMBO molecular …, 2021 - embopress.org
The immune responses and mechanisms limiting symptom progression in asymptomatic
cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized …

Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)

FY Chang, HC Chen, PJ Chen, MS Ho… - Journal of biomedical …, 2020 - Springer
Abstract On March 11, 2020, the World Health Organization declared the worldwide spread
of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as …

Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection

MJ Christie, AT Irving, SC Forster, BJ Marsland… - Science …, 2021 - science.org
In humans, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is highly
infective, often causes severe acute and/or long-term illness, and elicits a high rate of …