Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals

F Zhang, R Gan, Z Zhen, X Hu, X Li, F Zhou… - Signal transduction and …, 2020 - nature.com
The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has
affected more than eight million people. There is an urgent need to investigate how the …

SARS-CoV-2 in immunocompromised individuals

S DeWolf, JC Laracy, MA Perales, M Kamboj… - Immunity, 2022 - cell.com
Immunocompromised individuals and particularly those with hematologic malignancies are
at increased risk for SARS-CoV-2-associated morbidity and mortality due to immunologic …

[HTML][HTML] Host cell-intrinsic innate immune recognition of SARS-CoV-2

EA Madden, MS Diamond - Current opinion in virology, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of
2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical …

COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …

Early insights into immune responses during COVID-19

AL St John, APS Rathore - The Journal of Immunology, 2020 - journals.aai.org
Abstract Coronavirus disease-2019 (COVID-19) is caused by the newly emerged virus
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was recently declared …

Prevention and treatment of COVID‐19 disease by controlled modulation of innate immunity

V Schijns, EC Lavelle - European journal of immunology, 2020 - Wiley Online Library
The recent outbreak of coronavirus disease 2019 (COVID‐19), triggered by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses an enormous threat to global …

Deciphering the role of host genetics in susceptibility to severe COVID-19

ME Carter-Timofte, SE Jørgensen, MR Freytag… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following
infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst …

The impact of pre-existing comorbidities and therapeutic interventions on COVID-19

LA Callender, M Curran, SM Bates… - Frontiers in …, 2020 - frontiersin.org
Evidence from the global outbreak of SARS-CoV-2 has clearly demonstrated that individuals
with pre-existing comorbidities are at a much greater risk of dying from COVID-19. This is of …

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Y Jamilloux, T Henry, A Belot, S Viel, M Fauter… - Autoimmunity …, 2020 - Elsevier
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …

Innate immunity during SARS-CoV-2: evasion strategies and activation trigger hypoxia and vascular damage

S Amor, L Fernández Blanco… - Clinical & Experimental …, 2020 - academic.oup.com
Innate immune sensing of viral molecular patterns is essential for development of antiviral
responses. Like many viruses, SARS-CoV-2 has evolved strategies to circumvent innate …