During the past few years, crystallography of G protein–coupled receptors (GPCRs) has
experienced exponential growth, resulting in the determination of the structures of 16 distinct …

G protein-coupled receptors (GPCRs) are critical regulators of human physiology and make
up the largest single class of therapeutic drug targets. Although GPCRs regulate highly …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

G protein–coupled receptors (GPCRs) mediate the majority of cellular responses to external
stimuli. Upon activation by a ligand, the receptor binds to a partner heterotrimeric G protein …

G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically
important membrane protein family that recognizes a variety of environmental stimuli, and …

G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins
that have gained relevance as biological targets for pharmaceutical drug design. Although …

G protein–coupled receptors (GPCRs) are versatile molecular machines that regulate the
majority of physiological responses to chemically diverse hormones and neurotransmitters …

G protein-coupled receptors (GPCRs) are privileged structural scaffolds in biology that have
the versatility to regulate diverse physiological processes. Interestingly, many GPCR ligands …

For many years seven transmembrane domain G protein-coupled receptors (GPCRs) were
thought to exist and function exclusively as monomeric units. However, evidence both from …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …