Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
In a prospective-longitudinal study of a representative birth cohort, we tested why stressful
experiences lead to depression in some people but not in others. A functional polymorphism …
experiences lead to depression in some people but not in others. A functional polymorphism …
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
KP Lesch, D Bengel, A Heils, SZ Sabol, BD Greenberg… - Science, 1996 - science.org
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been
implicated in anxiety in humans and animal models and is the site of action of widely used …
implicated in anxiety in humans and animal models and is the site of action of widely used …
Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
MS Ansorge, M Zhou, A Lira, R Hen, JA Gingrich - Science, 2004 - science.org
Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and
anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown …
anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown …
The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression
NA Gillespie, JB Whitfield, BEN Williams… - Psychological …, 2005 - cambridge.org
Background. Serotonin is a good candidate for major depression. We attempted to replicate
the study by Caspi and colleagues [Science (2003) 301, 386–389] which reported a …
the study by Caspi and colleagues [Science (2003) 301, 386–389] which reported a …
Serotonin transporter genetic variation and the response of the human amygdala
A functional polymorphism in the promoter region of the human serotonin transporter gene
(SLC6A4) has been associated with several dimensions of neuroticism and …
(SLC6A4) has been associated with several dimensions of neuroticism and …
Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits
Evidence of marked variability in response among people exposed to the same
environmental risk implies that individual differences in genetic susceptibility might be at …
environmental risk implies that individual differences in genetic susceptibility might be at …
Gene-environment interactions in depression research: genetic polymorphisms and life-stress polyprocedures
SM Monroe, MW Reid - Psychological Science, 2008 - journals.sagepub.com
Recent studies on life stress, depression, and polymorphisms in the promoter region of the
serotonin transporter gene (5-HTTLPR) are characterized by powerful genetic techniques …
serotonin transporter gene (5-HTTLPR) are characterized by powerful genetic techniques …
Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)
BH Brummett, SH Boyle, IC Siegler, CM Kuhn… - Behavior genetics, 2008 - Springer
The short (s) variant of the serotonin transporter (5-HTT) gene linked functional polymorphic
region (5-HTTLPR) is associated with depression. Stressful life events, gender, and race …
region (5-HTTLPR) is associated with depression. Stressful life events, gender, and race …
Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene
Previous research has demonstrated that a polymorphism in the serotonin transporter gene
(5-HTTLPR) and adverse psychosocial circumstances interact to predict depression. The …
(5-HTTLPR) and adverse psychosocial circumstances interact to predict depression. The …
The serotonin transporter polymorphism (5‐HTTLPR): allelic variation and links with depressive symptoms
Background: We compare the genotype distribution for the serotonin transporter
polymorphism (5‐HTTLPR) in a sample of older Taiwanese adults with samples of various …
polymorphism (5‐HTTLPR) in a sample of older Taiwanese adults with samples of various …