Regulation of gene expression in eukaryotes is an extremely complex process. In this
review, we break down several critical steps, emphasizing new data and techniques that …

Control of eukaryotic gene expression involves combinatorial interactions between
transcription factors and regulatory sequences in the genome. In addition, chromatin …

Genome-scale analyses have allowed us to progress beyond studying gene expression at
the level of individual components of a given process by providing global information about …

The transcription of genomic information in eukaryotes is regulated in large part by
chromatin. How a diverse array of chromatin regulator (CR) proteins with different functions …

Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Eukaryotic transcriptional regulation requires the integration of complex signals by the
transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications …

Eukaryotic gene regulation involves a balance between packaging of the genome into
nucleosomes and enabling access to regulatory proteins and RNA polymerase …

Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Regulation of eukaryotic gene expression is far more complex than one might have
imagined 30 years ago. However, progress towards understanding gene regulatory …

Gene activation requires the cooperative activity of multiple transcription factors at cis-
regulatory elements (CREs). Yet, most transcription factors have short residence time …